Abstract

The mission of the Biostatistics Core is to support and help promote high quality, innovative research in the COAST projects by providing the COAST IV investigators with access to quality data and sophisticated statistical design and analysis. In order to fulfill this mission, the Core staff will collaborate in the design, execution and analysis of the laboratory and clinical research studies and the development and application of new statistical methods as needed by the projects. Core staff will function as collaborative members of research teams. Core staff will be available for advice on statistical issues in the design, conduct, and analysis of studies related to the COAST IV projects. Advice may be related to a project-specific activity or internal review of general issues faced by an investigator. Core staff will also provide on-going support for the COAST IV projects. Core staff will interact with project investigators to identify research questions of interest and the relevant variables within the COAST I, II, III and IV databases. The Biostatistics Core has developed a sophisticated and secure Oracle database system for entering and storing COAST 1,11 and III study data. The Oracle system will continue to be used to manage data on the COAST cohort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL070831-13
Application #
8871763
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
13
Fiscal Year
2015
Total Cost
$276,617
Indirect Cost
$107,718

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Higano, Nara S; Spielberg, David R; Fleck, Robert J et al. (2018) Neonatal Pulmonary Magnetic Resonance Imaging of Bronchopulmonary Dysplasia Predicts Short-Term Clinical Outcomes. Am J Respir Crit Care Med 198:1302-1311
Stein, Michelle M; Thompson, Emma E; Schoettler, Nathan et al. (2018) A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol 142:749-764.e3
Bønnelykke, Klaus; Coleman, Amaziah T; Evans, Michael D et al. (2018) Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses. Am J Respir Crit Care Med 197:589-594
Bashir, Hiba; Grindle, Kristine; Vrtis, Rose et al. (2018) Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens. J Allergy Clin Immunol 141:822-824.e9
Higano, Nara S; Bates, Alister J; Tkach, Jean A et al. (2018) Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging. J Pediatr Surg Case Rep 29:5-8
Ober, Carole; Sperling, Anne I; von Mutius, Erika et al. (2017) Immune development and environment: lessons from Amish and Hutterite children. Curr Opin Immunol 48:51-60
Hahn, Andrew D; Higano, Nara S; Walkup, Laura L et al. (2017) Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system. J Magn Reson Imaging 45:463-471
Rubner, Frederick J; Jackson, Daniel J; Evans, Michael D et al. (2017) Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence. J Allergy Clin Immunol 139:501-507
Turunen, Riitta; Vuorinen, Tytti; Bochkov, Yury et al. (2017) Clinical and Virus Surveillance After the First Wheezing Episode: Special Reference to Rhinovirus A and C Species. Pediatr Infect Dis J 36:539-544
Liu, Y-P; Rajamanikham, V; Baron, M et al. (2017) Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes. Clin Exp Allergy 47:371-382

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