Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL071659-04
Application #
7440912
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
4
Fiscal Year
2005
Total Cost
$420,820
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Swain, Steve D; Meissner, Nicole N; Siemsen, Dan W et al. (2012) Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness. Am J Respir Cell Mol Biol 46:290-8
Swain, Steve D; Meissner, Nicole; Han, Soo et al. (2011) Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens. Infect Immun 79:1905-14
Saperstein, Sara; Huyck, Heidie; Kimball, Elizabeth et al. (2009) The effects of interleukin-1beta in tumor necrosis factor-alpha-induced acute pulmonary inflammation in mice. Mediators Inflamm 2009:958658
Ehrenberg, Morton S; Friedman, Alan E; Finkelstein, Jacob N et al. (2009) The influence of protein adsorption on nanoparticle association with cultured endothelial cells. Biomaterials 30:603-10
Pryhuber, Gloria S; Huyck, Heidie L; Bhagwat, Samir et al. (2008) Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia. J Immunol 181:1409-19
Swain, Steve D; Han, Soo; Harmsen, Ann et al. (2007) Pulmonary hypertension can be a sequela of prior Pneumocystis pneumonia. Am J Pathol 171:790-9
Wang, Jing; Gigliotti, Francis; Bhagwat, Samir P et al. (2007) Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 292:L1495-505
Gigliotti, Francis; Crow, Elliott L; Bhagwat, Samir P et al. (2006) Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia. Infect Immun 74:6310-6
Yee, Min; Vitiello, Peter F; Roper, Jason M et al. (2006) Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol 291:L1101-11
Swain, Steve D; Meissner, Nicole N; Harmsen, Allen G (2006) CD8 T cells modulate CD4 T-cell and eosinophil-mediated pulmonary pathology in pneumocystis pneumonia in B-cell-deficient mice. Am J Pathol 168:466-75

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