Abstract

This is an application for support for an ongoing program devoted to final events in atherosclerosis, that is rupture of the atherosclerotic plaque. The hypothesis explored is that macrophage death plays a critical role in progression of the lesion. To test this hypothesis, we propose a combination of an in vitro assay designed to identify genes controlling macrophage death and an animal model already demonstrated to show spontaneous plaque rupture. Work done under this program has the potential to identify novel therapeutic approaches to dealing with the progression from existing atherosclerotic lesions to atherosclerotic lesions that become clinically significant.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL072262-04
Application #
7105581
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
4
Fiscal Year
2005
Total Cost
$494,286
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Kirkham, Erin M; Hatsukami, Thomas S; Heckbert, Susan R et al. (2017) Association between Snoring and High-Risk Carotid Plaque Features. Otolaryngol Head Neck Surg 157:336-344
Keire, Paul A; Bressler, Steven L; Mulvihill, Eileen R et al. (2016) Inhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo. Matrix Biol 50:67-81
Sun, Jie; Underhill, Hunter R; Hippe, Daniel S et al. (2012) Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage: a long-term time course study. JACC Cardiovasc Imaging 5:798-804
Balu, Niranjan; Yarnykh, Vasily L; Chu, Baocheng et al. (2011) Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI. Magn Reson Med 65:627-37
Iwata, Akiko; Morgan-Stevenson, Vicki; Schwartz, Barbara et al. (2010) Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury. PLoS One 5:e9103
Hatsukami, Thomas S; Yuan, Chun (2010) MRI in the early identification and classification of high-risk atherosclerotic carotid plaques. Imaging Med 2:63-75
Underhill, H R; Yuan, C; Yarnykh, V L et al. (2010) Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis. AJNR Am J Neuroradiol 31:487-93
Underhill, H R; Hatsukami, T S; Cai, J et al. (2010) A noninvasive imaging approach to assess plaque severity: the carotid atherosclerosis score. AJNR Am J Neuroradiol 31:1068-75
Underhill, Hunter R; Yuan, Chun; Yarnykh, Vasily L et al. (2009) Arterial remodeling in [corrected] subclinical carotid artery disease. JACC Cardiovasc Imaging 2:1381-9
Ota, Hideki; Yu, Wei; Underhill, Hunter R et al. (2009) Hemorrhage and large lipid-rich necrotic cores are independently associated with thin or ruptured fibrous caps: an in vivo 3T MRI study. Arterioscler Thromb Vasc Biol 29:1696-701

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