Dr. Eugene Podrez serves as Core Director. He has 4 years of hands on experience in performing the thrombosis models described below. He originally set up the intravital microscopy system while in the Department of Cell Biology and then developed his own system upon joining the Department of Molecular Cardiology. He has performed over one hundred experiments using this system, which culminated in his Nature Medicine manuscript in 2007 (1). Thus, he is in a position not only to direct but also trouble shot any issues that arise. He has trained Ms. Ma in the performance of the FeCI3 model, and she now has more than 2 years of experience in its performance. To perform the angiogenesis and platelet transfusion experiments, a new technologist will be hired. This person will be trained by Dr. Byzova, who has performed these experiments in her laboratory for some time. She has published on the various angiogenesis models (2-4) and has submitted a manuscript on the platelet transfusions models.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL073311-06
Application #
7657897
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2009-04-01
Project End
2014-03-31
Budget Start
2009-04-01
Budget End
2010-04-30
Support Year
6
Fiscal Year
2009
Total Cost
$172,490
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Szpak, Dorota; Izem, Lahoucine; Verbovetskiy, Dmitriy et al. (2018) ?M?2 Is Antiatherogenic in Female but Not Male Mice. J Immunol 200:2426-2438
Plow, Edward F; Wang, Yunmei; Simon, Daniel I (2018) The search for new antithrombotic mechanisms and therapies that may spare hemostasis. Blood 131:1899-1902
Sossey-Alaoui, Khalid; Pluskota, Elzbieta; Szpak, Dorota et al. (2018) The Kindlin-2 regulation of epithelial-to-mesenchymal transition in breast cancer metastasis is mediated through miR-200b. Sci Rep 8:7360
Gao, Detao; Podrez, Eugene A (2018) Characterization of covalent modifications of HDL apoproteins by endogenous oxidized phospholipids. Free Radic Biol Med 115:57-67
Bledzka, Kamila; Schiemann, Barbara; Schiemann, William P et al. (2017) The WAVE3-YB1 interaction regulates cancer stem cells activity in breast cancer. Oncotarget 8:104072-104089
Sossey-Alaoui, Khalid; Pluskota, Elzbieta; Bialkowska, Katarzyna et al. (2017) Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration. Cancer Res 77:5129-5141
Ding, Liang; Zhang, Lifang; Kim, Michael et al. (2017) Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway. J Biol Chem 292:9283-9293
Biswas, Sudipta; Zimman, Alejandro; Gao, Detao et al. (2017) TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With Hyperlipidemia. Circ Res 121:951-962
Wang, Yunmei; Gao, Huiyun; Shi, Can et al. (2017) Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIb?. Nat Commun 8:15559
Meller, Julia; Chen, Zhihong; Dudiki, Tejasvi et al. (2017) Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages. JCI Insight 2:

Showing the most recent 10 out of 105 publications