The specific proteolytic activation steps of blood coagulation are catalyzed by serine proteinases that are homologous to each other and to the archetypal serine proteinases

Public Health Relevance

The formation of a blood clot results from a series of very specific activation steps in which an inactive precursor in blood is cleaved at specific sites to form an active product. Our research is directed towards obtaining new insights into how these reactions of high specificity occur. The findings will reveal novel strategies for interfering with these reactions and for the treatment of life-threatening blood clots associated with a variety of human diseases

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL074124-06A1
Application #
7663365
Study Section
Special Emphasis Panel (ZHL1-PPG-J (F2))
Project Start
2009-04-01
Project End
2014-03-31
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
6
Fiscal Year
2009
Total Cost
$490,348
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Baroni, M; Pavani, G; Pinotti, M et al. (2015) Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation. Biochim Biophys Acta 1854:1351-6

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