Program Director/Principal Investigator (Last, First, Middle): l nSnnaSWamy, OH ram PROJECT SUMMARY(See instructions): This core will provide administrative support and oversight of the program project. An administrative assistant will provide support for financial management and administration of the program. She will be assisted by a part time work-study student, The administrative core will also organize monthly meetings to facilitate scientific exchange between program participants and provide a format for the evaluation of the scientific progress in individual projects. The core will also organize visits from members of both intramural and extramural advisory boards and organize a small seminar program. Funds are requested in Core A to support two yearly visits from Dr. James Huntington who is a key collaborator to the program.

Public Health Relevance


National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Special Emphasis Panel (ZHL1-PPG-J)
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Children's Hospital of Philadelphia
United States
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Thalji, Nabil K; Camire, Rodney M (2017) Rendering factor Xa zymogen-like as a therapeutic strategy to treat bleeding. Curr Opin Hematol 24:453-459
Vadivel, Kanagasabai; Kumar, Yogesh; Bunce, Matthew W et al. (2017) Interaction of factor V B-domain acidic region with its basic region and with TFPI/TFPI2: Structural insights from molecular modeling studies. Int Biol Rev 1:
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Bradford, Harlan N; Krishnaswamy, Sriram (2016) The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase. J Biol Chem 291:11114-23
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Baroni, M; Pavani, G; Pinotti, M et al. (2015) Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation. Biochim Biophys Acta 1854:1351-6
George, L A; Thalji, N K; Raffini, L J et al. (2015) Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen-like FXa(I16L). J Thromb Haemost 13:1694-8

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