The objective of the Metabolism core is to provide the to PPG investigators the scientific and technical support for the execution of biochemical analyses of blood and myocardial tissue samples from all four Projects in the PPG. The Core will perform metabolic and isotopic tracer analysis of blood and tissue from the dogs studied in Projects 1, 2 and 3, and will oversee the experiments with doubly labeled water in mice and dogs in Project 1. The Core will also assess the expression and activity of selected proteins, measure the content of key regulatory metabolites (e.g ATP, lactate, etc), measure mRNA expression for selected genes, and plasma hormone levels. The measurement of Inflamatory cytokines for Project 1 will be performed by the Core. All of the expertise and equipment necessary for these measurements is in place.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL074237-07
Application #
8127899
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
7
Fiscal Year
2010
Total Cost
$278,846
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
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