Abstract

The laboratory core will serve three functions for the program. First, the laboratory core will perform analysis of lymphocyte receptor repertoires using a method developed by Drs. Ogle, Platt, Cascalho, and West. Second, the core will obtain laboratory studies, such as measurement of viral load and autoantibody levels needed for two or more projects. Third, the core will provide a standardized review and coordination of analysis of tissue samples for diagnosis of rejection (or lack thereof), as relevant to the goals of the program or interactions between two or more projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL079067-02
Application #
7312643
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2006-07-01
Project End
2010-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$181,640
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Urschel, Simon; West, Lori J (2016) ABO-incompatible heart transplantation. Curr Opin Pediatr 28:613-9
Cascalho, Marilia; Platt, Jeffrey L (2016) Harnessing B cells in immunotherapy. Immunotherapy 8:237-9
Dijke, Esme I; Platt, Jeffrey L; Blair, Paul et al. (2016) B cells in transplantation. J Heart Lung Transplant 35:704-10
Yamada, Chisa; Ramon, Daniel S; Cascalho, Marilia et al. (2015) Efficacy of plasmapheresis on donor-specific antibody reduction by HLA specificity in post-kidney transplant recipients. Transfusion 55:727-35; quiz 726
Platt, Jeffrey L; Wrenshall, Lucile E; Johnson, Geoffrey B et al. (2015) Heparan Sulfate Proteoglycan Metabolism and the Fate of Grafted Tissues. Adv Exp Med Biol 865:123-40
Barbosa, Rita R; Silva, Susana L; Silva, Sara P et al. (2014) Reduced BAFF-R and increased TACI expression in common variable immunodeficiency. J Clin Immunol 34:573-83
Tsuji, Shoichiro; Stein, Lucas; Kamada, Nobuhiko et al. (2014) TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen. J Clin Invest 124:4857-66
Platt, Jeffrey L; Cascalho, Marilia (2013) New and old technologies for organ replacement. Curr Opin Organ Transplant 18:179-85
Cascalho, Marilia I; Chen, Brian J; Kain, Mandy et al. (2013) The paradoxical functions of B cells and antibodies in transplantation. J Immunol 190:875-9
Lynch, R J; Silva, I A; Chen, B J et al. (2013) Cryptic B cell response to renal transplantation. Am J Transplant 13:1713-23

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