Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL084205-05
Application #
8259412
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2013-04-30
Budget Start
2011-05-01
Budget End
2013-04-30
Support Year
5
Fiscal Year
2011
Total Cost
$70,667
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Leko, Vid; Varnum-Finney, Barbara; Li, Hongzhe et al. (2012) SIRT1 is dispensable for function of hematopoietic stem cells in adult mice. Blood 119:1856-60
Varnum-Finney, Barbara; Halasz, Lia M; Sun, Mingyi et al. (2011) Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest 121:1207-16
Welcker, Markus; Larimore, Elizabeth A; Frappier, Lori et al. (2011) Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. Mol Cell Biol 31:1214-24
Dahlberg, Ann; Delaney, Colleen; Bernstein, Irwin D (2011) Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood 117:6083-90
Butler, Jason M; Nolan, Daniel J; Vertes, Eva L et al. (2010) Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell 6:251-64
Laurenti, Elisa; Varnum-Finney, Barbara; Wilson, Anne et al. (2008) Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3:611-24
Minella, Alex C; Loeb, Keith R; Knecht, Andrea et al. (2008) Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev 22:1677-89
Varnum-Finney, Barbara; Dallas, Mari H; Kato, Keizo et al. (2008) Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus. Blood 111:2615-20
Yang, Qi; Kardava, Lela; St Leger, Anthony et al. (2008) E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol 181:5885-94
Aoyama, Keisuke; Delaney, Colleen; Varnum-Finney, Barbara et al. (2007) The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation. Stem Cells 25:2488-97