supply resources, and equipment. Finally, the Program Director, together with Mr. Haas, will appropriately review requests for allocation offunds for travel, and priority will be given to Investigators presenting original research related to the ProgramProject and its integrating theme.Scientific Responsibilities A vital part of the Program Director's responsibilities is to continually challenge the Program Project leadersso that they are continuing to pursue new scientific ideas related to the central theme and ensure optimal effortto achieve the Specific Aims as outlined. To succeed in this effort will require optimal use of both the Internaland External Advisory Committees. The Internal Advisory Committee has been formed, and if the ProgramProject Grant is funded, an External Advisory Committee will be formed as well.The primary responsibility of the Advisory Committees will be to evaluate the general progress andconduct of the PPG, as well as the level of interaction among the PPG participants. Specifically:provide input on the interrelatedness of the research and the role of each individual project in thecentral theme of the PPG; provide input on the collaborative aspects of the PPG and evaluate inter-project utilization of research findings and resources; provide their expertise on any other activity topromote closer collaboration and communication among projects. The Program Director will thenschedule meeting(s) with project leaders to discuss. Prior to the meeting, study and projectrecommendations received from the Advisory Committee(s) will be distributed to all Project/Coreleaders. The Program and Project Directors will then: a) examine data from the protocols todetermine criteria for modification or termination of protocol(s) to more efficiently address the centralhypothesis of the PPG ; b) monitor the synergy and interrelationships among the projects and cores;c) forward a summary to Advisory Committee members of the specific actions taken to address theirrecommendations; d) schedule additional meetings as necessary.PHS 398/2590 (Rev.09/04, Reissued4/2006) Page 277 Continuation Format Page

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL085307-01A1
Application #
7327511
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
1
Fiscal Year
2007
Total Cost
$114,970
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Saad, Ahmed; Dietz, Allan B; Herrmann, Sandra M S et al. (2017) Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease. J Am Soc Nephrol 28:2777-2785
Wang, Wei; Saad, Ahmed; Herrmann, Sandra M et al. (2016) Changes in inflammatory biomarkers after renal revascularization in atherosclerotic renal artery stenosis. Nephrol Dial Transplant 31:1437-43
Kashyap, Sonu; Warner, Gina M; Hartono, Stella P et al. (2016) Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension. Am J Physiol Renal Physiol 310:F372-84
Kwon, Soon Hyo; Tang, Hui; Saad, Ahmed et al. (2016) Differential Expression of microRNAs in Urinary Extracellular Vesicles Obtained From Hypertensive Patients. Am J Kidney Dis 68:331-332
Saad, Ahmed; Zhu, Xiang-Yang; Herrmann, Sandra et al. (2016) Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia. Stem Cell Res Ther 7:128
Saad, Ahmed; Wang, Wei; Herrmann, Sandra M S et al. (2016) Atherosclerotic renal artery stenosis is associated with elevated cell cycle arrest markers related to reduced renal blood flow and postcontrast hypoxia. Nephrol Dial Transplant 31:1855-1863
Zhu, Xiang-Yang; Ebrahimi, Behzad; Eirin, Alfonso et al. (2015) Renal Vein Levels of MicroRNA-26a Are Lower in the Poststenotic Kidney. J Am Soc Nephrol 26:1378-88
Rhee, Eugene P; Clish, Clary B; Pierce, Kerry A et al. (2015) Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension. J Hypertens 33:836-42
Saad, Ahmed; Herrmann, Sandra M; Textor, Stephen C (2015) Chronic renal ischemia in humans: can cell therapy repair the kidney in occlusive renovascular disease? Physiology (Bethesda) 30:175-82
Widmer, R Jay; Flammer, Andreas J; Lerman, Lilach O et al. (2015) The Mediterranean diet, its components, and cardiovascular disease. Am J Med 128:229-38

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