Abstract

Core C: Administrative Core The Administrative Core will provide support for the Program Director in coordinating the overall Program Project Grant on a day-to-day basis. The specific responsibilities of the Administrative Core include: [1] overseeing the distribution of scientific core resources to the four individual research projects;[2] managing the weekly PPG Seminars including scheduling, arranging for travel and itineraries for visiting outside speakers;[3] developing and maintaining a website for the PPG to permit outside investigators access to services and reagents developed through this PPG;[4] preparing annual budget reports as required by the University of Michigan and the National Institutes of Health;[5] organizing the Program review by the External Advisory Board and the Internal Advisory Board;[6] overall post-award management including fiscal oversight and assurance of compliance with NIH guidelines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL089407-04
Application #
8247048
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2011-04-01
Project End
2013-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
4
Fiscal Year
2011
Total Cost
$227,669
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Obi, Andrea T; Andraska, Elizabeth; Kanthi, Yogendra et al. (2017) Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost 117:339-348
Obi, Andrea T; Andraska, Elizabeth; Kanthi, Yogendra et al. (2016) Gram-Negative Pneumonia Alters Large-Vein Cell-Adhesion Molecule Profile and Potentiates Experimental Stasis Venous Thrombosis. J Vasc Res 53:186-195
Wu, Jianbo; Strawn, Tammy L; Luo, Mao et al. (2015) Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-?V?3 integrin cross talk. Arterioscler Thromb Vasc Biol 35:111-20
Obi, A T; Diaz, J A; Ballard-Lipka, N L et al. (2014) Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism. J Thromb Haemost 12:1353-63
Obi, Andrea T; Diaz, Jose A; Ballard-Lipka, Nicole L et al. (2014) Low-molecular-weight heparin modulates vein wall fibrotic response in a plasminogen activator inhibitor 1-dependent manner. J Vasc Surg Venous Lymphat Disord 2:441-450.e1
Li, Shih-Hon; Reinke, Ashley A; Sanders, Karen L et al. (2013) Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc Natl Acad Sci U S A 110:E4941-9
Diaz, Jose A; Alvarado, Christine M; Wrobleski, Shirley K et al. (2013) The electrolytic inferior vena cava model (EIM) to study thrombogenesis and thrombus resolution with continuous blood flow in the mouse. Thromb Haemost 109:1158-69
Patterson, K A; Zhang, X; Wrobleski, S K et al. (2013) Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects. Thromb Res 131:268-76
Shuster, Katherine A; Wrobleski, Shirley K; Hawley, Angela E et al. (2013) Prothrombotic effects of thrombolytic therapy in a rat (Rattus norvegicus) model of venous thrombolysis. Comp Med 63:244-51
Sashindranath, Maithili; Sales, Eunice; Daglas, Maria et al. (2012) The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans. Brain 135:3251-64

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