Abstract

The Molecular Assessment Core will be primarily located in the Translational Research Laboratory (TRL), the same building which houses the Center for Sleep and Circadian Neurobiology. The functioning of the Molecular Assessment Core will take advantage of existing facilities and the sophisticated equipment already available within the Translational Research Laboratory. The Molecular Assessment Core will act as a central facility to collect, process and analyze the large number of incoming blood and urine samples generated by the Projects 02 and 03. Importantly, the Molecular Assessment Core will ensure quality control of all samples collected by the proposed projects. The objectives of the Molecular Assessment Core are to: 1) standardize blood and urine collection between sites, 2) ensure proper handling and storage of samples, 3) code, record and monitor incoming samples, 4) ensure quality control of assays and 5) provide a centralized facility for assays. The Molecular Assessment Core will be under the leadership of Dr. Allan I. Pack, with support staff consisting of two experienced research specialists.

Public Health Relevance

Understanding the basis of individual differences in consequences of sleep apnea requires assessment of effects at a molecular level. This Core provides this both for the project in humans (Project 02) and in mice (Project 03).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL094307-09
Application #
9756445
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Laposky, Aaron D
Project Start
Project End
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
9
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Feng, Yuan; Keenan, Brendan T; Wang, Stephen et al. (2018) Dynamic Upper Airway Imaging during Wakefulness in Obese Subjects with and without Sleep Apnea. Am J Respir Crit Care Med 198:1435-1443
Sands, Scott A; Edwards, Bradley A; Terrill, Philip I et al. (2018) Phenotyping Pharyngeal Pathophysiology using Polysomnography in Patients with Obstructive Sleep Apnea. Am J Respir Crit Care Med 197:1187-1197
Pien, Grace W; Ye, Lichuan; Keenan, Brendan T et al. (2018) Changing Faces of Obstructive Sleep Apnea: Treatment Effects by Cluster Designation in the Icelandic Sleep Apnea Cohort. Sleep 41:
Mazzotti, Diego R; Lim, Diane C; Sutherland, Kate et al. (2018) Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity. Physiol Meas 39:09TR01
Sands, Scott A; Edwards, Bradley A; Terrill, Philip I et al. (2018) Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy. Eur Respir J 52:
Keenan, Brendan T; Kim, Jinyoung; Singh, Bhajan et al. (2018) Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis. Sleep 41:
van Hees, Vincent Theodoor; Sabia, S; Jones, S E et al. (2018) Estimating sleep parameters using an accelerometer without sleep diary. Sci Rep 8:12975
Shulman, Rachel; Cohen, Debbie L; Grandner, Michael A et al. (2018) Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications. J Clin Hypertens (Greenwich) 20:1712-1720
Gao, Xiaoling; Azarbarzin, Ali; Keenan, Brendan T et al. (2017) Heritability of Heart Rate Response to Arousals in Twins. Sleep 40:
Lyons, M Melanie; Keenan, Brendan T; Li, Junxin et al. (2017) Symptomless Multi-Variable Apnea Prediction Index Assesses Obstructive Sleep Apnea Risk and Adverse Outcomes in Elective Surgery. Sleep 40:

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