The overall goal of Project 1 is to examine the prognostic significance of mental stress-induced ischemia in a large and contemporary population of CAD patients with and without exercise-induced ischemia, and to examine the role of genetic variations in the a- and ^ff-adrenergic receptor genes and other gene systems known to regulate the reactivity response to stress. Specifically, we propose to address the following aims:
Aim 1 : Among CAD patients with and without exercise-induced ischemia, examine the relationship between mental stress-induced ischemia and adverse outcomes defined as: a) death and myocardial infarction (Ml); and b) a composite index of death, nonfatal Ml, hospitalization for unstable angina, and need for revascularization (coronary bypass surgery or percutaneous intervention). We will test the hypothesis that CAD patients with mental stress-induced ischemia will have higher rates of adverse outcomes than those without mental stress-induced ischemia irrespective of the presence of exercise-induced ischemia.
Aim 2 : Among CAD patients with and without exercise-induced ischemia, examine the relationship between genetic polymorphisms of the a- and;ff-adrenergic receptors and other candidate genes related to the stress response and mental stress-induced ischemia. We will test the hypothesis that these genetic polymorphisms will be associated with mental stress-induced ischemia and thus the allele and/or genotype frequencies in CAD patients without mental stress-induced ischemia will differ from those in patients with mental stress-induced ischemia.
| Hammadah, Muhammad; Sullivan, Samaah; Pearce, Brad et al. (2018) Inflammatory response to mental stress and mental stress induced myocardial ischemia. Brain Behav Immun 68:90-97 |
| Vaccarino, Viola; Sullivan, Samaah; Hammadah, Muhammad et al. (2018) Mental Stress-Induced-Myocardial Ischemia in Young Patients With Recent Myocardial Infarction: Sex Differences and Mechanisms. Circulation 137:794-805 |
| Schultz, William M; Kelli, Heval M; Lisko, John C et al. (2018) Socioeconomic Status and Cardiovascular Outcomes: Challenges and Interventions. Circulation 137:2166-2178 |
| Pimple, Pratik; Hammadah, Muhammad; Wilmot, Kobina et al. (2018) Chest Pain and Mental Stress-Induced Myocardial Ischemia: Sex Differences. Am J Med 131:540-547.e1 |
| Sullivan, Samaah; Hammadah, Muhammad; Al Mheid, Ibhar et al. (2018) Sex Differences in Hemodynamic and Microvascular Mechanisms of Myocardial Ischemia Induced by Mental Stress. Arterioscler Thromb Vasc Biol 38:473-480 |
| Samman Tahhan, Ayman; Hammadah, Muhammad; Raad, Mohamad et al. (2018) Progenitor Cells and Clinical Outcomes in Patients With Acute Coronary Syndromes. Circ Res 122:1565-1575 |
| Hajjar, Ihab; Hayek, Salim S; Goldstein, Felicia C et al. (2018) Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study. J Neuroinflammation 15:17 |
| Bremner, J Douglas; Campanella, Carolina; Khan, Zehra et al. (2018) Brain Correlates of Mental Stress-Induced Myocardial Ischemia. Psychosom Med 80:515-525 |
| Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2018) Association Between High-Sensitivity Cardiac Troponin Levels and Myocardial Ischemia During Mental Stress and Conventional Stress. JACC Cardiovasc Imaging 11:603-611 |
| Samman Tahhan, Ayman; Hammadah, Muhammad; Kelli, Heval Mohamed et al. (2018) Circulating Progenitor Cells and Racial Differences. Circ Res 123:467-476 |
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