Abstract

The purpose of the molecular probes and imaging core is 1: to synthesize imaging probes (opfical, MR and multimodal) capable of cell tracking, fate mapping, and reporting on molecular events, and 2: to supply imaging expertise and equipment to detect these probes in vivo and in vitro. The four projects within the PPG share a number of interrelated goals in terms of functional and molecular imaging. The purpose of the imaging core is to provide a centralized source of chemical and imaging expertise to the investigators of the PPG, and to develop imaging protocols and techniques that will benefit all the investigators and reduce the amount of redundant effort needed to achieve the imaging goals of the projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL108795-04
Application #
8661263
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
$177,444
Indirect Cost
$61,189

  Institution

Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Cheng, Zhongjian; Shen, Xinggui; Jiang, Xiaohua et al. (2018) Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: Role of insufficient hydrogen sulfide. Redox Biol 16:215-225
Sato, Kohei; Hendricks, Mark P; Palmer, Liam C et al. (2018) Peptide supramolecular materials for therapeutics. Chem Soc Rev 47:7539-7551
Gupta, Rajesh; Mackie, Alexander R; Misener, Sol et al. (2018) Endothelial smoothened-dependent hedgehog signaling is not required for sonic hedgehog induced angiogenesis or ischemic tissue repair. Lab Invest 98:682-691
Rotz, Matthew W; Holbrook, Robert J; MacRenaris, Keith W et al. (2018) A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes. Bioconjug Chem 29:3544-3549
Tsai, FuNien; Homan, Philip J; Agrawal, Hemant et al. (2017) Bim suppresses the development of SLE by limiting myeloid inflammatory responses. J Exp Med 214:3753-3773
Rai, Rahul; Verma, Suresh K; Kim, David et al. (2017) A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis. Epigenetics 12:1004-1013
Eren, Mesut; Place, Aaron T; Thomas, Paul M et al. (2017) PAI-1 is a critical regulator of FGF23 homeostasis. Sci Adv 3:e1603259
Hendricks, Mark P; Sato, Kohei; Palmer, Liam C et al. (2017) Supramolecular Assembly of Peptide Amphiphiles. Acc Chem Res 50:2440-2448
Makinde, Hadijat M; Just, Talia B; Cuda, Carla M et al. (2017) The Role of Microglia in the Etiology and Evolution of Chronic Traumatic Encephalopathy. Shock 48:276-283
Sleep, Eduard; Cosgrove, Benjamin D; McClendon, Mark T et al. (2017) Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation. Proc Natl Acad Sci U S A 114:E7919-E7928

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