The purpose of the Administrative and Biostatistics Core (Core A) is to coordinate the administrative and fiscal activities of the PPG, to provide biostatistics support for all of the Projects, and to ensure rigorous experimental design and data analysis for all the Projects. Dr. Linton will provide oversight for all functions of Core A. Mr. Nicholas Jenkins, Grants Manager, will work closely with Dr. Linton to provide fiscal oversight and management of the budgetary aspects of the PPG?s Projects and Cores, including compliance with institutional policy and implementation of grant policy for post award management. Mr. Jenkins will assist with budgets related to grant submissions, including competing and noncompeting renewals. Ms. Lawrence will oversee the financial aspects of the administration of the budget. She will supervise and coordinate communication with the Grants Manager and the Administrative Officer. Maria Peng, Administrative Officer, will prepare monthly budget statements for the Projects and Cores for the Investigators. She will be responsible for PPG reports and administration of finances for the service Cores and the Projects. Ms. Lawrence and Ms. Bartkus, the administrative assistant, will be jointly responsible for generating purchase orders for equipment and reagents for all of the PPG Projects and Cores, and for expenditure reconciliation. Ms. Bartkus will also help with arranging the monthly meetings of PPG Project Leaders, investigators and Core Leaders, organize seminars, meetings with advisors and handle PPG related travel. She will ensure that all human subject and animal use documentation is current. The Biostatistics portion of Core A will provide statistical expertise for all projects and investigators to ensure rigor and reproducibility for all PPG projects. Drs. Ye and Du will continue to work closely with project leaders and will be available to all PPG investigators to provide state-of-the-art statistical support. To ensure statistical reproducibility, for each PPG-associated analysis performed, a statistical report in HTML or PDF format will be generated, which will document the R programming codes and any simulation seeds used in the analysis. Additionally, all model development procedures will be internally validated using cross-validation or bootstrap methods. The Biostatistics Core supports all 4 Projects. Bioinformatics support will be provided in Core D: The Non-Coding RNA and Bioinformatics Core.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL116263-06A1
Application #
10089336
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Liu, Lijuan
Project Start
2014-06-01
Project End
2025-12-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
6
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
May-Zhang, Linda S; Yermalitsky, Valery; Huang, Jiansheng et al. (2018) Modification by isolevuglandins, highly reactive ?-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function. J Biol Chem 293:9176-9187
Allen, Ryan M; Zhao, Shilin; Ramirez Solano, Marisol A et al. (2018) Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins. J Extracell Vesicles 7:1506198
Mueller, Paul A; Zhu, Lin; Tavori, Hagai et al. (2018) Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages. Circulation 138:1850-1863
Li, Kang; Rodosthenous, Rodosthenis S; Kashanchi, Fatah et al. (2018) Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop. JCI Insight 3:
Babaev, Vladimir R; Ding, Lei; Zhang, Youmin et al. (2018) Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice. Arterioscler Thromb Vasc Biol :ATVBAHA118312206
Kaseda, R; Tsuchida, Y; Gamboa, J L et al. (2018) Angiotensin receptor blocker vs ACE inhibitor effects on HDL functionality in patients on maintenance hemodialysis. Nutr Metab Cardiovasc Dis 28:582-591
Kaseda, Ryohei; Tsuchida, Yohei; Yang, Hai-Chun et al. (2018) Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism. BMC Nephrol 19:17
Babaev, Vladimir R; Huang, Jiansheng; Ding, Lei et al. (2018) Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice. Front Immunol 9:215
Byram, Kevin W; Oeser, Annette M; Linton, MacRae F et al. (2018) Exercise is Associated With Increased Small HDL Particle Concentration and Decreased Vascular Stiffness in Rheumatoid Arthritis. J Clin Rheumatol 24:417-421
Sedgeman, Leslie R; Beysen, Carine; Allen, Ryan M et al. (2018) Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes. Am J Physiol Gastrointest Liver Physiol :

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