The Core C (Physiology Core) for the MCW program project grant, entitled ?Renal Mechanisms in Blood Pressure Control?, will support program project investigators with comprehensive biochemical, microscopy, electrophysiological, and phenotyping services to assess physiological and pathophysiological function of the kidney in the control of blood pressure. The need for Core C is apparent considering the current heavy use and anticipated use in the proposed protocols. Throughout the history of the PPG, Core C has provided centralized, standardized research services that have enabled program investigators to engage in cutting edge research. The overall goal of Core C is to assist program project investigators with the application of many of the basic and more-comprehensive analyses relevant to the study of kidney physiology and its relationship to the blood pressure control at the cellular, organ, and whole animal level. Multiple approaches will be offered, including biochemical analysis, chronic blood pressure measurement by telemetry or indwelling catheters, laser-Doppler flowmetry, GFR measurement, biosensors, fluorescence probes, and electrophysiology analysis in freshly isolated tubules. Core C will serve as an invaluable resource for the project investigators to define the specific mechanisms that lead to the control of blood pressure and kidney diseases. Core staff will also assist in experimental design and training of the laboratory staff, and participate in data collection and analysis.
Physiology Core C is an essential component of this PPG and will support all three projects. The scientific projects share the common goal of providing novel insights into the mechanisms and functional pathways underlying the development of salt-sensitive hypertension and renal damage. The overall goal of Core C is to provide all PPG project investigators access to modern equipment and technical expertise needed to perform a wide variety of high quality assays and approaches necessary to conduct proposed studies.
| Mattson, David L (2018) Heat stress nephropathy and hyperuricemia. Am J Physiol Renal Physiol 315:F757-F758 |
| Abais-Battad, Justine M; Lund, Hayley; Fehrenbach, Daniel J et al. (2018) Rag1-null Dahl SS rats reveal that adaptive immune mechanisms exacerbate high protein-induced hypertension and renal injury. Am J Physiol Regul Integr Comp Physiol 315:R28-R35 |
| Bukowy, John D; Dayton, Alex; Cloutier, Dustin et al. (2018) Do computers dream of electric glomeruli? Kidney Int 94:635 |
| Spires, Denisha; Ilatovskaya, Daria V; Levchenko, Vladislav et al. (2018) Protective role of Trpc6 knockout in the progression of diabetic kidney disease. Am J Physiol Renal Physiol 315:F1091-F1097 |
| Bukowy, John D; Dayton, Alex; Cloutier, Dustin et al. (2018) Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections. J Am Soc Nephrol 29:2081-2088 |
| Regal, Jean F; Laule, Connor F; McCutcheon, Luke et al. (2018) The complement system in hypertension and renal damage in the Dahl SS rat. Physiol Rep 6:e13655 |
| Abais-Battad, Justine M; Lund, Hayley; Fehrenbach, Daniel J et al. (2018) Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension. Hypertension :HYPERTENSIONAHA11811994 |
| Williams, Anna Marie; Liu, Yong; Regner, Kevin R et al. (2018) Artificial intelligence, physiological genomics, and precision medicine. Physiol Genomics 50:237-243 |
| Palygin, Oleg; Miller, Bradley S; Nishijima, Yoshinori et al. (2018) Endothelin receptor A and p66Shc regulate spontaneous Ca2+ oscillations in smooth muscle cells controlling renal arterial spontaneous motion. FASEB J :fj201800776RR |
| Wade, Brittany; Petrova, Galina; Mattson, David L (2018) Role of immune factors in angiotensin II-induced hypertension and renal damage in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol 314:R323-R333 |
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