Core A Administrative Project Abstract The administrative core will oversee the coordination of the Program as a whole. Specifically, it will be in charge of supervising the organizational structure and chain of responsibility. Weekly lab meetings, monthly program-wide meetings, quarterly internal advisory board meetings and annual external advisory board meetings will be coordinated and documented through this core. A biannual translational speaker series will also be coordinated by the core, in conjunction with advisory board meetings. The core will maintain records, interface with the NHLBI Program Officer, and maintain the Program's web site. The core will ensure optimal interactions between component projects and cores, and between the program and other relevant institutional programs. The core will supervise the proper and thorough execution of the data safety monitoring plan, and will aim to ensure that diversity targets are met. The core will ensure proper dissemination of information and resources acquired during the project. The core will ensure timely completion of all translational milestones to enable the Program to have an optimal clinical benefit for patients with severe asthma and cystic fibrosis.

Public Health Relevance

Core A Administrative Project Narrative The administrative core will oversee the coordination of the Program as a whole. Specifically, it will be in charge of supervising the organizational structure and chain of responsibility. Weekly lab meetings, monthly program-wide meetings, quarterly internal advisory board meetings and annual external advisory board meetings will be coordinated and documented through this core. A biannual translational speaker series will also be coordinated by the core, in conjunction with advisory board meetings. The core will maintain records, interface with the NHLBI Program Officer, and maintain the Program's web site. The core will ensure optimal interactions between component projects and cores, and between the program and other relevant institutional programs. The core will supervise the proper and thorough execution of the data safety monitoring plan, and will aim to ensure that diversity targets are met. The core will ensure proper dissemination of information and resources acquired during the project. The core will ensure timely completion of all translational milestones to enable the Program to have an optimal clinical benefit for patients with severe asthma and cystic fibrosis.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL128192-03
Application #
9520384
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Noel, Patricia
Project Start
Project End
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Zhou, Hua-Lin; Stomberski, Colin T; Stamler, Jonathan S (2018) Cross Talk Between S-Nitrosylation and Phosphorylation Involving Kinases and Nitrosylases. Circ Res 122:1485-1487
Powell, Cameron J; Ramaswamy, Raghavendran; Kelsen, Anne et al. (2018) Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii. Proc Natl Acad Sci U S A 115:E10548-E10555
Stsiapura, Vitali I; Bederman, Ilya; Stepuro, Ivan I et al. (2018) S-Nitrosoglutathione formation at gastric pH is augmented by ascorbic acid and by the antioxidant vitamin complex, Resiston. Pharm Biol 56:86-93
Rizza, Salvatore; Cardaci, Simone; Montagna, Costanza et al. (2018) S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy. Proc Natl Acad Sci U S A 115:E3388-E3397