Core C, the Mouse Breeding and Microsurgery and Procedure Core will serve all three Projects over all five years of the Program. There are two major functions of Core C: (1) The Mouse Breeding function will provide transgenic and null mice bred into specific genetic backgrounds to each of the three projects of the Program. This component will provide services to mate and genotype the animals required for Projects 1-2-3. (2) The Mouse Microsurgery and Procedure function will standardize microsurgery procedures and procedures carried out by the Projects, including the aorta transplant surgery (Project 1), fat transplantation (Projects 2&3), bone marrow transplantation (Project 1) and glucose and insulin tolerance tests (Projects 1,2,&3).
Diabetes and obesity are major causes of morbidity and mortality, at least in part through the increased risk for cardiovascular disease. Our goal is to understand the mechanisms underlying macrophage dysfunction in these conditions that lead to insulin resistance, diabetes and cardiovascular complications.
| Koelwyn, Graeme J; Corr, Emma M; Erbay, Ebru et al. (2018) Regulation of macrophage immunometabolism in atherosclerosis. Nat Immunol 19:526-537 |
| Moore, Kathryn J; Koplev, Simon; Fisher, Edward A et al. (2018) Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2). J Am Coll Cardiol 72:2181-2197 |
| Hadi, Tarik; Boytard, Ludovic; Silvestro, Michele et al. (2018) Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun 9:5022 |
| Barrett, Tessa J; Murphy, Andrew J; Goldberg, Ira J et al. (2017) Diabetes-mediated myelopoiesis and the relationship to cardiovascular risk. Ann N Y Acad Sci 1402:31-42 |
