? ADMINISTRATIVE CORE A The administrative core will provide support for the science being performed in each of the three projects. Dr. Sinoway will meet on a regular basis with each of the project leaders. In these meetings, discussions regarding new directions and potential areas of future collaboration between the projects will be discussed. A leadership team including Dr. Sinoway, Dr. Leuenberger, Dr. Kaufman, Dr. Li, Dr. Ruiz- Velasco, Dr. Thomas and Dr. Yang will meet bi-weekly. Each of the investigators in this PPG will receive administrative support from this core and rely heavily on Ms. Stoner's administrative and organizational skills. She will be involved in the preparation of manuscripts, grant renewal applications (competitive and non-competitive), and scheduling the seminar series and various meetings including those of the internal and external advisory boards. Each of the investigators in this PPG will receive financial and regulatory support from Ms. Gray. She handles both pre and post award paperwork, and will be the IRB liaison for the group. Salary support for Stoner and Gray are provided by the Penn State College of Medicine. Engineering support (including repair and fabrication of novel devices for all 3 Projects) will be provided by Dr. Herr, and biostatistical support will be provided by Allen Kunselman. Funding for computer expenses, publications costs and travel are budgeted within this Core and will be shared between the three Projects.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Reid, Diane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Pennsylvania State University
United States
Zip Code
Estrada, Juan A; Kaufman, Marc P (2018) µ-Opioid receptors inhibit the exercise pressor reflex by closing N-type calcium channels but not by opening GIRK channels in rats. Am J Physiol Regul Integr Comp Physiol 314:R693-R699
Xing, Jihong; Lu, Jian; Liu, Jiahao et al. (2018) Local Injections of Superoxide Dismutase Attenuate the Exercise Pressor Reflex in Rats with Femoral Artery Occlusion. Front Physiol 9:39
Miller, Amanda J; Luck, J Carter; Kim, Danielle Jin-Kwang et al. (2018) Peripheral revascularization attenuates the exercise pressor reflex and increases coronary exercise hyperemia in peripheral arterial disease. J Appl Physiol (1985) 125:58-63
Kuczmarski, J Matthew; Unrath, Kellee; Thomas, Gail D (2018) Exaggerated cardiovascular responses to treadmill running in rats with peripheral arterial insufficiency. Am J Physiol Heart Circ Physiol 314:H114-H121
Xing, Jihong; Lu, Jian; Li, Jianhua (2018) Role of TNF-? in Regulating the Exercise Pressor Reflex in Rats With Femoral Artery Occlusion. Front Physiol 9:1461
Harms, Jonathan; Stone, Audrey J; Kaufman, Marc P (2018) Peripheral µ-opioid receptors attenuate the responses of group III and IV afferents to contraction in rats with simulated peripheral artery disease. J Neurophysiol 119:2052-2058
Miller, Amanda J; Luck, J Carter; Kim, Danielle Jin-Kwang et al. (2017) Blood pressure and leg deoxygenation are exaggerated during treadmill walking in patients with peripheral artery disease. J Appl Physiol (1985) 123:1160-1165
Xing, Jihong; Li, Jianhua (2017) TRPA1 Function in Skeletal Muscle Sensory Neurons Following Femoral Artery Occlusion. Cell Physiol Biochem 42:2307-2317
Farrag, Mohamed; Drobish, Julie K; Puhl, Henry L et al. (2017) Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia. J Physiol 595:7167-7183
Xing, Jihong; Li, Jianhua (2017) Proteinase-Activated Receptor-2 Sensitivity of Amplified TRPA1 Activity in Skeletal Muscle Afferent Nerves and Exercise Pressor Reflex in Rats with Femoral Artery Occlusion. Cell Physiol Biochem 44:163-171