Unhappily married individuals report poorer mental and physical health than either happily married or divorced people of the same race, sex, and age. This project, an intensive, longitudinal investigation of satisfied and dissatisfied newlyweds, will provide very valuable data on psychological and physiological mechanisms that are thought to lead to the observed health differences. A sample of 90 couples who have been married for six months will be recruited, half of whom are high in marital satisfaction, and half who are low; while newlyweds generally report high marital satisfaction, about 20% are already disenchanted in the first year, and these initial differences in marital satisfaction are associated with much greater differences two years later. Psychological data (behavioral and self-report) and physiological data (endocrine and immune function) will be obtained from the couples during a 24-hour admission to the Ohio State University Clinical Research Center (CRC), with the full assessment repeated two years later on the same couples. Immunological and self-report data will also be gathered in the one-year interval between CRC admissions, and health data will be collected every three months. The prospective design will provide important data on the relationships among psychological, endocrinological, and immunological changes related to changes in marital quality. The ubiquity of marital discord makes it a particularly important area for this multifaceted interdisciplinary research effort.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH044660-05
Application #
3845831
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Jaremka, Lisa M; Glaser, Ronald; Malarkey, William B et al. (2013) Marital distress prospectively predicts poorer cellular immune function. Psychoneuroendocrinology 38:2713-9
Heffner, Kathi L; Kiecolt-Glaser, Janice K; Loving, Timothy J et al. (2004) Spousal support satisfaction as a modifier of physiological responses to marital conflict in younger and older couples. J Behav Med 27:233-54
Kiecolt-Glaser, Janice K; Bane, Cynthia; Glaser, Ronald et al. (2003) Love, marriage, and divorce: newlyweds' stress hormones foreshadow relationship changes. J Consult Clin Psychol 71:176-88
Cacioppo, John T; Kiecolt-Glaser, Janice K; Malarkey, William B et al. (2002) Autonomic and glucocorticoid associations with the steady-state expression of latent Epstein-Barr virus. Horm Behav 42:32-41
Glaser, R; Friedman, S B; Smyth, J et al. (1999) The differential impact of training stress and final examination stress on herpesvirus latency at the United States Military Academy at West Point. Brain Behav Immun 13:240-51
Glaser, R; Kiecolt-Glaser, J K; Malarkey, W B et al. (1998) The influence of psychological stress on the immune response to vaccines. Ann N Y Acad Sci 840:649-55
Kiecolt-Glaser, J K; Glaser, R; Cacioppo, J T et al. (1998) Marital stress: immunologic, neuroendocrine, and autonomic correlates. Ann N Y Acad Sci 840:656-63
Kiecolt-Glaser, J K; Glaser, R; Cacioppo, J T et al. (1997) Marital conflict in older adults: endocrinological and immunological correlates. Psychosom Med 59:339-49
Wu, H; Devi, R; Malarkey, W B (1996) Localization of growth hormone messenger ribonucleic acid in the human immune system--a Clinical Research Center study. J Clin Endocrinol Metab 81:1278-82
Wu, H; Devi, R; Malarkey, W B (1996) Expression and localization of prolactin messenger ribonucleic acid in the human immune system. Endocrinology 137:349-53

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