Abstract

This core assays in year 1, 430 samples for urine for catecholamines (norepinephrine and epinephrine) and an identical number for cortisol at baseline and at multiple time points after CBSM intervention in Projects 0002 and 0004. The data obtained will test hypotheses regarding the efficacy of CBSM intervention in adaptation to behavioral challenge. This core will assay in year 1, 636 samples of plasma for ACTH and identical numbers for plasma cortisol and catecholamines obtained in this project at baseline and different time points to examine the kinetics of response to evaluative speech challenge. In addition, tox screens (cocaine, opiates, marijuana, amphetamine and alcohol) will be carried out on all the samples of urine in order to examine compliance of the study subjects to adhere to a drug-free regimen needed to investigate the efficacy of CBSM in the Program Project. Overall the assays carried out in this core will provide data to test the hypothesis that CBSM intervention will reduce the sympathetic arousal. This core interacts with all the projects and additionally, interacts with Immunology Core, to test a relationship between endocrines and immune status in subjects undergoing CBSM intervention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH049548-09
Application #
6468014
Study Section
Project Start
2001-03-01
Project End
2002-04-30
Budget Start
Budget End
Support Year
9
Fiscal Year
2001
Total Cost
$124,146
Indirect Cost

  Institution

Name
University of Miami Coral Gables
Department
Type
DUNS #
City
Coral Gables
State
FL
Country
United States
Zip Code
33146

  Publications

Erlen, Judith A; Tamres, Lisa K; Reynolds, Nancy et al. (2015) Assessing usual care in clinical trials. West J Nurs Res 37:288-98
Petersen, Maya L; LeDell, Erin; Schwab, Joshua et al. (2015) Super Learner Analysis of Electronic Adherence Data Improves Viral Prediction and May Provide Strategies for Selective HIV RNA Monitoring. J Acquir Immune Defic Syndr 69:109-18
Fekete, Erin M; Seay, Julia; Antoni, Michael H et al. (2014) Oxytocin, social support, and sleep quality in low-income minority women living with HIV. Behav Sleep Med 12:207-21
Simoni, Jane M; Huh, David; Wang, Yan et al. (2014) The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study. AIDS Behav 18:2285-90
Rosen, M I; Black, A C; Arnsten, J H et al. (2013) Association between use of specific drugs and antiretroviral adherence: findings from MACH 14. AIDS Behav 17:142-7
Wilson, Ira B; Bangsberg, David R; Shen, Jie et al. (2013) Heterogeneity among studies in rates of decline of antiretroviral therapy adherence over time: results from the multisite adherence collaboration on HIV 14 study. J Acquir Immune Defic Syndr 64:448-54
Liu, Honghu; Wilson, Ira B; Goggin, Kathy et al. (2013) MACH14: a multi-site collaboration on ART adherence among 14 institutions. AIDS Behav 17:127-41
Simoni, Jane M; Huh, David; Wilson, Ira B et al. (2012) Racial/Ethnic disparities in ART adherence in the United States: findings from the MACH14 study. J Acquir Immune Defic Syndr 60:466-72
Genberg, Becky L; Wilson, Ira B; Bangsberg, David R et al. (2012) Patterns of antiretroviral therapy adherence and impact on HIV RNA among patients in North America. AIDS 26:1415-23
Wagner, Glenn J; Goggin, Kathy; Remien, Robert H et al. (2011) A closer look at depression and its relationship to HIV antiretroviral adherence. Ann Behav Med 42:352-60

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