The overall goal of this project is to investigate selected attributes and mechanisms of emotion regulatory skills in the young offspring of mothers with childhood-onset depression that may contribute to such offspring being at high risk for eventual depressive and related disorders. We will examine the following domains: (1) emotion expression and regulatory strategies in the child, (2) adjustment and cognitive style in the mother, and (3) maternal interactive behavior related to the emotion-regulation in the child. The sample will involve a longitudinal comparison of the offspring of mothers with childhood-onset depression, the offspring of probands with childhood-onset anxiety disorder, and the offspring of probands with no childhood-onset diagnosis. Assessments of these three domains will take place annually in the laboratory. Our overall hypothesis is that there exists a characteristic confluence of child factors, maternal characteristics, and parent-child interactive factors that put the offspring of childhood-onset depressed probands at risk for depression. An accelerated longitudinal design will be utilized so that group differences can be evaluated-both cross-sectionally and longitudinally from ages 1 to 9 during the five-year span of the project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH056193-02
Application #
6111746
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Nusslock, Robin; Shackman, Alexander J; McMenamin, Brenton W et al. (2018) Comorbid anxiety moderates the relationship between depression history and prefrontal EEG asymmetry. Psychophysiology 55:
Panaite, Vanessa; Bylsma, Lauren M; Kovacs, Maria et al. (2018) Dysregulated behavioral responses to hedonic probes among youth with depression histories and their high-risk siblings. Emotion :
Daches, Shimrit; Kovacs, Maria; George, Charles J et al. (2017) Childhood adversity predicts reduced physiological flexibility during the processing of negative affect among adolescents with major depression histories. Int J Psychophysiol 121:22-28
Kovacs, Maria; Lopez-Duran, Nestor L; George, Charles et al. (2017) The Development of Mood Repair Response Repertories: I. Age-Related Changes Among 7- to 14-Year-Old Depressed and Control Children and Adolescents. J Clin Child Adolesc Psychol :1-10
Yaroslavsky, Ilya; Rottenberg, Jonathan; Bylsma, Lauren M et al. (2016) Parasympathetic nervous system activity predicts mood repair use and its effectiveness among adolescents with and without histories of major depression. J Abnorm Psychol 125:323-36
Kovacs, Maria; Bylsma, Lauren M; Yaroslavsky, Ilya et al. (2016) Positive Affectivity is Dampened in Youths with Histories of Major Depression and Their Never-Depressed Adolescent Siblings. Clin Psychol Sci 4:661-674
Bylsma, Lauren M; Yaroslavsky, Ilya; Rottenberg, Jonathan et al. (2016) Familiality of mood repair responses among youth with and without histories of depression. Cogn Emot 30:807-16
Kovacs, Maria; Obrosky, Scott; George, Charles (2016) The course of major depressive disorder from childhood to young adulthood: Recovery and recurrence in a longitudinal observational study. J Affect Disord 203:374-381
Kovacs, Maria; Yaroslavsky, Ilya; Rottenberg, Jonathan et al. (2015) Mood repair via attention refocusing or recall of positive autobiographical memories by adolescents with pediatric-onset major depression. J Child Psychol Psychiatry 56:1108-17
Rimay, Timea; Benak, Istvan; Kiss, Eniko et al. (2015) BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. Psychiatr Genet 25:249-55

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