The overall goal of this project is to investigate selected attributes and mechanisms of emotion regulatory skills in the young offspring of mothers with childhood-onset depression that may contribute to such offspring being at high risk for eventual depressive and related disorders. We will examine the following domains: (1) emotion expression and regulatory strategies in the child, (2) adjustment and cognitive style in the mother, and (3) maternal interactive behavior related to the emotion-regulation in the child. The sample will involve a longitudinal comparison of the offspring of mothers with childhood-onset depression, the offspring of probands with childhood-onset anxiety disorder, and the offspring of probands with no childhood-onset diagnosis. Assessments of these three domains will take place annually in the laboratory. Our overall hypothesis is that there exists a characteristic confluence of child factors, maternal characteristics, and parent-child interactive factors that put the offspring of childhood-onset depressed probands at risk for depression. An accelerated longitudinal design will be utilized so that group differences can be evaluated-both cross-sectionally and longitudinally from ages 1 to 9 during the five-year span of the project.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Program Projects (P01)
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University of Pittsburgh
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Nusslock, Robin; Shackman, Alexander J; McMenamin, Brenton W et al. (2018) Comorbid anxiety moderates the relationship between depression history and prefrontal EEG asymmetry. Psychophysiology 55:
Panaite, Vanessa; Bylsma, Lauren M; Kovacs, Maria et al. (2018) Dysregulated behavioral responses to hedonic probes among youth with depression histories and their high-risk siblings. Emotion :
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Kovacs, Maria; Yaroslavsky, Ilya; Rottenberg, Jonathan et al. (2015) Mood repair via attention refocusing or recall of positive autobiographical memories by adolescents with pediatric-onset major depression. J Child Psychol Psychiatry 56:1108-17
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