The Laboratory of Neurobiology of the Medical Sciences Campus of the University of Puerto Rico is an interdepartmental research facility, which offers both to U.P.R. and visiting scientists and students the environment and equipment necessary to conduct research projects on the morphology (including ultrastucture), electrical activity and pharmacological sensitivity of excitable cells and tissues. The collecting facilities of the Laboratory of Neurobiology offer access to the rich Caribbean marine fauna as well as to the many scientifically interesting invertebrate and plant species of the rain forests of this island. Present projects include: I. Regulation and axonal transport of Na,K-ATPase; II. Comparative aspects of excitation phenomena: a) Central connections and functional significance of the spine nerves of Diadema, b) Mechanical and pharmacological properties of the spine ligaments in sea urchin, c) Ultrastructure and properties of the dorsal fin muscle of Hippocampus, d) Excitation-contraction coupling in Ascaris esophagus; III. a) Characterization of muscle membrane receptors in Sabellastarte, b) Actions of ciguatoxin on animal cells; IV. Modulation of cholinergic receptors by succinylated derivatives of buffer TES; V. Anatomical basis of color vision in ground squirrels; VI. Kinetic and pharmacological properties of calcium channels activated by sulfhydryl reagents in crustacean muscle.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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Neurological Disorders Program Project Review B Committee (NSPB)
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University of Puerto Rico Med Sciences
Schools of Medicine
San Juan
United States
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Delgado, Nadia; Vallejo, Deborah; Miller, Mark W (2012) Localization of serotonin in the nervous system of Biomphalaria glabrata, an intermediate host for schistosomiasis. J Comp Neurol 520:3236-55
Levi, Rafael; Selverston, Allen I (2006) Mechanisms underlying type I mGluR-induced activation of lobster gastric mill neurons. J Neurophysiol 96:3378-88
Duprey-Diaz, Mildred V; Soto, Ileana; Blagburn, Jonathan M et al. (2002) Changes in brain-derived neurotrophic factor and trkB receptor in the adult Rana pipiens retina and optic tectum after optic nerve injury. J Comp Neurol 454:456-69
Diaz-Rios, Manuel; Oyola, Eduardo; Miller, Mark W (2002) Colocalization of gamma-aminobutyric acid-like immunoreactivity and catecholamines in the feeding network of Aplysia californica. J Comp Neurol 445:29-46
Kuffler, D (2000) Can regeneration be promoted within the spinal cord? P R Health Sci J 19:241-52
Blanco, R E; Lopez-Roca, A; Soto, J et al. (2000) Basic fibroblast growth factor applied to the optic nerve after injury increases long-term cell survival in the frog retina. J Comp Neurol 423:646-58
Delgado, J Y; Oyola, E; Miller, M W (2000) Localization of GABA- and glutamate-like immunoreactivity in the cardiac ganglion of the lobster Panulirus argus. J Neurocytol 29:605-19
Zheng, M; Kuffler, D P (2000) Guidance of regenerating motor axons in vivo by gradients of diffusible peripheral nerve-derived factors. J Neurobiol 42:212-9
Hill, E S; Latalladi, G; Kuffler, D P (1999) Dissociated adult Rana pipiens motoneuron growth cones turn up concentration gradients of denervated peripheral nerve-released factors. Neurosci Lett 277:87-90
Blanco, R E; Rosado, J; Padilla, J et al. (1999) Ultrastructural studies of dorsal root axons regenerating through adult frog optic and sciatic nerves. Microsc Res Tech 46:310-8

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