The Institute of Neurobiology of the Medical Sciences Campus of the University of Puerto Rico is an interdisciplinary, interdepartmental research facility devoted to the study of the structure and function of the nervous system with an emphasis on comparative cellular studies. It offers investigators and students from Puerto Rico, the rest of the United States and the Americas, as well as Europe, access to specimens of the rich Caribbean marine, terrestrial and fresh water fauna to be used as experimental models for neurobiological investigations. The studies are aimed at shedding light on cellular processes which must be understood to provide a rational basis for the diagnosis and treatment of a variety of neurological diseases. The Institute has collecting and holding facilities as well as the services of informed local naturalists. It acts as a focus around which a growing number of researchers interested in the various aspects of the neurosciences is reaching the critical mass necessary for productive interactions and the growth of collaborative efforts. The purpose of this program project grant is to provide funds, which, in addition to those provided by the Commonwealth of Puerto Rico, will support the general core activities (Histology, Zoology, Communication and Support Services) as well as many of the research efforts of the permanent faculty at the Institute. The present projects are: I. Development of synapses between identified neurons (Blagburn). II. Regulation and axonal transport of Na,K-ATPase (Corey-Specht). III. Neural control of the sea urchin spine ligament (del Castillo). IV. Anatomical basis of color vision in ground squirrels (Lugo-Garcia) V. Long-term interactions of neurons and glia (Orkand). VI. Modulation of crustacean muscle (Zuazaga).

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS007464-22
Application #
3099279
Study Section
(SRC)
Project Start
1976-09-01
Project End
1992-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
22
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Type
Overall Medical
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00936
Delgado, Nadia; Vallejo, Deborah; Miller, Mark W (2012) Localization of serotonin in the nervous system of Biomphalaria glabrata, an intermediate host for schistosomiasis. J Comp Neurol 520:3236-55
Levi, Rafael; Selverston, Allen I (2006) Mechanisms underlying type I mGluR-induced activation of lobster gastric mill neurons. J Neurophysiol 96:3378-88
Diaz-Rios, Manuel; Oyola, Eduardo; Miller, Mark W (2002) Colocalization of gamma-aminobutyric acid-like immunoreactivity and catecholamines in the feeding network of Aplysia californica. J Comp Neurol 445:29-46
Duprey-Diaz, Mildred V; Soto, Ileana; Blagburn, Jonathan M et al. (2002) Changes in brain-derived neurotrophic factor and trkB receptor in the adult Rana pipiens retina and optic tectum after optic nerve injury. J Comp Neurol 454:456-69
Kuffler, D (2000) Can regeneration be promoted within the spinal cord? P R Health Sci J 19:241-52
Blanco, R E; Lopez-Roca, A; Soto, J et al. (2000) Basic fibroblast growth factor applied to the optic nerve after injury increases long-term cell survival in the frog retina. J Comp Neurol 423:646-58
Delgado, J Y; Oyola, E; Miller, M W (2000) Localization of GABA- and glutamate-like immunoreactivity in the cardiac ganglion of the lobster Panulirus argus. J Neurocytol 29:605-19
Zheng, M; Kuffler, D P (2000) Guidance of regenerating motor axons in vivo by gradients of diffusible peripheral nerve-derived factors. J Neurobiol 42:212-9
Hill, E S; Latalladi, G; Kuffler, D P (1999) Dissociated adult Rana pipiens motoneuron growth cones turn up concentration gradients of denervated peripheral nerve-released factors. Neurosci Lett 277:87-90
Blanco, R E; Rosado, J; Padilla, J et al. (1999) Ultrastructural studies of dorsal root axons regenerating through adult frog optic and sciatic nerves. Microsc Res Tech 46:310-8

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