Abstract

We employ several approaches to attempting to understand the etiology and pathogenesis of multiple sclerosis. We will continue attempts to recover a virus or identify virus antigen in brain tissue of patients with MS. We will use human tissues in culture and animal model systems in vivo and in vitro to study the behavior of known neurotropic viruses, virus latency, and attempt to improve virus detection systems. We will study immunologic alterations associated with MS, with particular attention to compartmentalization of the immune response within the nervous system as compared with non-nervous system tissues. We will continue to focus on the oligodendrocyte as a possible target cell in MS, and employ isolated oligodendrocytes for immunologic and virologic studies related to MS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS011037-14
Application #
3099338
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1976-09-01
Project End
1988-03-31
Budget Start
1986-09-01
Budget End
1988-03-31
Support Year
14
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104