The proposed research is an interdisciplinary, intedepartmental collaborative effort to enable us to explore local cerebral glucose metabolism in the brain of man and how it is altered in various physiologic and pathologic situations. Such an exploration is now possible for the first time due to the development of the 18F-fluorodeoxyglucose method for the measurement of local cerebral glucose metabolism in man. There is extensive data in the literature suggesting a close link in the brain among functional activity, metabolism and blood flow. Thus, with an increase in functional activity in a region of the brain due to a specific stimulus one would expect an increase in the local metabolic rate and local perfusion. The proposed studies thus will not only provide us with important new information concerning local cerebral glucose metabolism per se, but also can be used to map the regions of the brain that are activated by a specific stimulus. The physiologic stimuli to be investigated are visual and cognitive tasks. In addition, the effects of pathologic conditions on local cerebral metabolism and local cerebral perfusion will be examined. These conditions are stroke, epilepsy, Alzheimer's disease, and brain tumor.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS014867-09A1
Application #
3099477
Study Section
(SRC)
Project Start
1979-01-01
Project End
1991-12-31
Budget Start
1986-09-29
Budget End
1987-12-31
Support Year
9
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Rothstein, R D; Stecker, M; Reivich, M et al. (1996) Use of positron emission tomography and evoked potentials in the detection of cortical afferents from the gastrointestinal tract. Am J Gastroenterol 91:2372-6
Kumar, A; Newberg, A; Alavi, A et al. (1993) Regional cerebral glucose metabolism in late-life depression and Alzheimer disease: a preliminary positron emission tomography study. Proc Natl Acad Sci U S A 90:7019-23