Renewal of support for five years is requested for a program of research related to injury of neurons of the vertebrate spinal cord. The general goal of this program project continues to be to gain insight into the nature of the fundamental mechanisms associated with regeneration of neurites and/or functional recovery after injury to spinal cord neurons. The projects address issues ranging from functional recovery in cold blooded vertebrates to mammalian models of clinical syndromes. The projects are multidisciplinary in approach, combining physiological. morphological and histochemical/molecular techniques. Most of the projects derive from results obtained during previous years of support. Three of the projects (2, 3, and 6) are directed at the nature or bases of changes in motor function, skeletal or autonomic. After injury of spinal neurons. Two projects (1 and 2) concern the mechanisms if altered sensory function following injury to central or peripheral afferent pathways. One project (5) examines the possibility that causalgic states following periphoral nerve injury may result from altered interactions between synpathetic efferents and nociceptive afferents. While each of the six projects will be carried out by an independent team of investigators, the teams share a common interest in the consequences of injury to spinal neurons, use many of the same techniques, and depend on core facilities to accomplish their research goals.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Schools of Medicine
Chapel Hill
United States
Zip Code
Arvanian, V L; Mendell, L M (2001) Acute modulation of synaptic transmission to motoneurons by BDNF in the neonatal rat spinal cord. Eur J Neurosci 14:1800-8
Vincler, M; Maixner, W; Vierck, C J et al. (2001) Estrous cycle modulation of nociceptive behaviors elicited by electrical stimulation and formalin. Pharmacol Biochem Behav 69:315-24
Vierck Jr, C J; Light, A R (2000) Allodynia and hyperalgesia within dermatomes caudal to a spinal cord injury in primates and rodents. Prog Brain Res 129:411-28
Arvanov, V L; Seebach, B S; Mendell, L M (2000) NT-3 evokes an LTP-like facilitation of AMPA/kainate receptor-mediated synaptic transmission in the neonatal rat spinal cord. J Neurophysiol 84:752-8
Berg, J S; Farel, P B (2000) Developmental regulation of sensory neuron number and limb innervation in the mouse. Brain Res Dev Brain Res 125:21-30
Shea, V K; Cai, R; Crepps, B et al. (2000) Sensory fibers of the pelvic nerve innervating the Rat's urinary bladder. J Neurophysiol 84:1924-33
Light, A R; Willcockson, H H (1999) Spinal laminae I-II neurons in rat recorded in vivo in whole cell, tight seal configuration: properties and opioid responses. J Neurophysiol 82:3316-26
Munson, J B; Johnson, R D; Mendell, L M (1999) Neurotrophin-3 and maintenance of muscle afferent function. Prog Brain Res 123:157-63
Perl, E R (1999) Causalgia, pathological pain, and adrenergic receptors. Proc Natl Acad Sci U S A 96:7664-7
Mendell, L M; Albers, K M; Davis, B M (1999) Neurotrophins, nociceptors, and pain. Microsc Res Tech 45:252-61

Showing the most recent 10 out of 126 publications