PROJECT 3SEROTONIN AND SLEEP DISORDERED BREATHING IN PARKINSON DISEASESleep disturbance and excessive daytime somnolence are important non-motor/non-dopaminergicfeatures of Parkinson disease (PD). Sleep disruption in PD is likely multifactorial but recent evidencesuggests a high prevalence of sleep disordered breathing in PD, a surprising finding in view of thetendency for PD subjects to lose weight during their illness. PD is clearly a multisystemneurodegeneration with evidence indicating degeneration of central serotoninergic systems. Caudalbrainstem serotoninergic neurons are key actors in controlling upper airway patency during sleep anddegeneration of this group of neurons would be a plausible cause of sleep disordered breathing in PD.Our hypothesis is that loss of caudal brainstem serotoninergic neurons causes SDB in PD. We willevaluate this hypothesis by comparing the caudal brainstem [11C]DASB binding, a measure ofserotoninergic neurons, in PD subjects with and without SDB. We predict greater loss of caudal brainstem[11C]DASB binding in PD subjects with SBD than in PD subjects without SDB. We predict an inversecorrelation between indices of SDB and caudal brainstem [11C]DASB binding in PD subjects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS015655-26A1
Application #
7590146
Study Section
Special Emphasis Panel (ZNS1-SRB-E (26))
Project Start
Project End
Budget Start
2008-09-15
Budget End
2009-06-30
Support Year
26
Fiscal Year
2008
Total Cost
$89,775
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Bohnen, Nicolaas I; Kanel, Prabesh; Müller, Martijn L T M (2018) Molecular Imaging of the Cholinergic System in Parkinson's Disease. Int Rev Neurobiol 141:211-250
Rektor, Ivan; Bohnen, Nicolaas I; Korczyn, Amos D et al. (2018) An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group. Parkinsonism Relat Disord 49:9-16
Kim, Kamin; Bohnen, Nicolaas I; Müller, Martijn L T M et al. (2018) Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease. Neuroimage :
Beaulieu, Mélanie L; Müller, Martijn L T M; Bohnen, Nicolaas I (2018) Peripheral neuropathy is associated with more frequent falls in Parkinson's disease. Parkinsonism Relat Disord 54:46-50
Bohnen, Nicolaas I; Grothe, Michel J; Ray, Nicola J et al. (2018) Recent advances in cholinergic imaging and cognitive decline-Revisiting the cholinergic hypothesis of dementia. Curr Geriatr Rep 7:1-11
Nejad-Davarani, Siamak; Koeppe, Robert A; Albin, Roger L et al. (2018) Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV. Mol Psychiatry :
Kotagal, Vikas; Albin, Roger L; Müller, Martijn L T M et al. (2018) Cardiovascular Risk Factor Burden in Veterans and Non-Veterans with Parkinson Disease. J Parkinsons Dis 8:153-160
Bohnen, Nicolaas I; Müller, Martijn L T M; Frey, Kirk A (2017) Molecular Imaging and Updated Diagnostic Criteria in Lewy Body Dementias. Curr Neurol Neurosci Rep 17:73
Chou, Kelvin L; Gilman, Sid; Bohnen, Nicolaas I (2017) Association between autonomic dysfunction and fatigue in Parkinson disease. J Neurol Sci 377:190-192
Kim, Kamin; Müller, Martijn L T M; Bohnen, Nicolaas I et al. (2017) The cortical cholinergic system contributes to the top-down control of distraction: Evidence from patients with Parkinson's disease. Neuroimage :

Showing the most recent 10 out of 146 publications