Core A: Cyclotron/Radiochemistry (MR Kilbourn) This Core will provide the clinical research projects and the Clinical Core with PET radiopharmaceuticals for measuring nigrostriatal dopamine terminals ([11C]DTBZ), serotonin nerve terminals ([11C]DASB), acetylcholine nerve terminals ([11C]PMP), brain fibrillary afi amyloid deposits ([11C]PIB), and myocardial sympathetic nerve terminals ([11C]HED). All of these PET radiotracers are presently in regular production and human research imaging use in our laboratories. The Core will provide high-quality research radiotracers meeting requirements for human administrations, and will track and monitor reagents and components, synthesis results, and quality control metrics in accordance with applicable medical, University, State, and Federal requirements. The Core includes a comprehensive quality assurance program.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-E)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Bohnen, Nicolaas I; Kanel, Prabesh; Müller, Martijn L T M (2018) Molecular Imaging of the Cholinergic System in Parkinson's Disease. Int Rev Neurobiol 141:211-250
Rektor, Ivan; Bohnen, Nicolaas I; Korczyn, Amos D et al. (2018) An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group. Parkinsonism Relat Disord 49:9-16
Kim, Kamin; Bohnen, Nicolaas I; Müller, Martijn L T M et al. (2018) Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease. Neuroimage :
Beaulieu, Mélanie L; Müller, Martijn L T M; Bohnen, Nicolaas I (2018) Peripheral neuropathy is associated with more frequent falls in Parkinson's disease. Parkinsonism Relat Disord 54:46-50
Bohnen, Nicolaas I; Grothe, Michel J; Ray, Nicola J et al. (2018) Recent advances in cholinergic imaging and cognitive decline-Revisiting the cholinergic hypothesis of dementia. Curr Geriatr Rep 7:1-11
Nejad-Davarani, Siamak; Koeppe, Robert A; Albin, Roger L et al. (2018) Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV. Mol Psychiatry :
Kotagal, Vikas; Albin, Roger L; Müller, Martijn L T M et al. (2018) Cardiovascular Risk Factor Burden in Veterans and Non-Veterans with Parkinson Disease. J Parkinsons Dis 8:153-160
Bohnen, Nicolaas I; Müller, Martijn L T M; Frey, Kirk A (2017) Molecular Imaging and Updated Diagnostic Criteria in Lewy Body Dementias. Curr Neurol Neurosci Rep 17:73
Chou, Kelvin L; Gilman, Sid; Bohnen, Nicolaas I (2017) Association between autonomic dysfunction and fatigue in Parkinson disease. J Neurol Sci 377:190-192
Kim, Kamin; Müller, Martijn L T M; Bohnen, Nicolaas I et al. (2017) The cortical cholinergic system contributes to the top-down control of distraction: Evidence from patients with Parkinson's disease. Neuroimage :

Showing the most recent 10 out of 146 publications