Core-- Trophic Factor Support

Snider, William D.

Abstract

CORE-F: Growth Factor Support, will supply materials and technical support for the projects delineating the role of neurotrophins in somatosensory development. The Growth Factor Support Core will provide nerve growth factor (NGF), antibodies to NGF and NGF receptors, determination of antibody specificity by Western Blotting, bioassays of growth factor and antibody concentrations in the sera of experimental animals, cDNAs for neurotrophins and neurotrophin receptors, and expertise and technical support for in situ hybridization histochemistry. The Growth Factor Support CORE provides a centralized location for the synthesis of these materials and the performance of these procedures.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Program Projects (P01)
• Project #: 2P01NS017763-12
• Application #: 3782797
• Support Year: 12
• Fiscal Year: 1993

Institution

• Name: Washington University
• DUNS #: 062761671
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63130

Publications

Tychsen, Lawrence; Wong, Agnes Ming-Fong; Burkhalter, Andreas (2004) Paucity of horizontal connections for binocular vision in V1 of naturally strabismic macaques: Cytochrome oxidase compartment specificity. J Comp Neurol 474:261-75

Dagnew, Elias; Latchamsetty, Kalyan; Erinjeri, Joseph P et al. (2003) Glutamate receptor blockade alters the development of intracortical connections in rat barrel cortex. Somatosens Mot Res 20:77-84

Boero, J; Qin, W; Cheng, J et al. (2003) Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: changing patterns in development and with increased activity. Mol Cell Biochem 244:69-76

Arikan, Rasim; Blake, Nicquet M J; Erinjeri, Joseph P et al. (2002) A method to measure the effective spread of focally injected muscimol into the central nervous system with electrophysiology and light microscopy. J Neurosci Methods 118:51-7

Carmichael, S T; Wei, L; Rovainen, C M et al. (2001) New patterns of intracortical projections after focal cortical stroke. Neurobiol Dis 8:910-22

Miller, B; Blake, N M; Erinjeri, J P et al. (2001) Postnatal growth of intrinsic connections in mouse barrel cortex. J Comp Neurol 436:17-31

Mosconi, T; Snider, W D; Jacquin, M F (2001) Neurotrophin receptor expression in retrogradely labeled trigeminal nociceptors--comparisons with spinal nociceptors. Somatosens Mot Res 18:312-21

Epley, K D; Shainberg, M J; Lueder, G T et al. (2001) Pediatric secondary lens implantation in the absence of capsular support. J AAPOS 5:301-6

Scott, C; Gusdorf, G; Tychsen, L (2000) Automated cover testing for binocular misalignment in awake monkeys using spectacle- mounted liquid crystal shutters. Binocul Vis Strabismus Q 15:59-66

Stark, K L; Kaufman, B; Lee, B C et al. (1999) Visual recovery after a year of craniopharyngioma-related amaurosis: report of a nine-year-old child and a review of pathophysiologic mechanisms. J AAPOS 3:366-71