The overall goal of this project remains the delineation of neural systems underlying language, by means of special experiments conducted in patients with focal brain damage. The first specific aim is to map the neural basis of the lexicon. The studies focus on the systems supporting lexical access, which we hypothesize to be based on left temporal cortices. The second specific aim relates to the processing of visuomotor linguistic signs, such as those used in American Sign Language (ASL). We will investigate the neural systems required for representing and accessing such signs, by studying the acquisition of ASL lexicon in hearing patients with a wide range of focal damage in left and right hemispheres. Also, we will continue to assess the clinical value of traditional diagnostic categories of aphasia, by investigating the consistency of anatomo-clinical correlations in our database, and to study the neural basis of auditory perception. The results will contribute to a more precise formulation of the neural basis of language, at systems level, and in particular, to further specification of the neural and cognitive architectures pertaining to lexical access and lexical representation. The results will shed light on the diagnosis and physiopathology of the aphasias, and assist in the development of programs to rehabilitate the large number of stroke and head injury victims who develop language impairments. Our approach capitalizes on the unique opportunities afforded by the study of adult humans with focal brain injury, and seeks to advance knowledge of language at both the neural and psychological levels.

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Mehta, Sonya; Inoue, Kayo; Rudrauf, David et al. (2016) Segregation of anterior temporal regions critical for retrieving names of unique and non-unique entities reflects underlying long-range connectivity. Cortex 75:1-19
Immordino-Yang, Mary Helen; Yang, Xiao-Fei; Damasio, Hanna (2016) Cultural modes of expressing emotions influence how emotions are experienced. Emotion 16:1033-9
Scherer, Aaron M; Taber-Thomas, Bradley C; Tranel, Daniel (2015) A neuropsychological investigation of decisional certainty. Neuropsychologia 70:206-13
Ceschin, Rafael; Wisnowski, Jessica L; Paquette, Lisa B et al. (2015) Developmental synergy between thalamic structure and interhemispheric connectivity in the visual system of preterm infants. Neuroimage Clin 8:462-72
Philippi, Carissa L; Tranel, Daniel; Duff, Melissa et al. (2015) Damage to the default mode network disrupts autobiographical memory retrieval. Soc Cogn Affect Neurosci 10:318-26
Guzmán-Vélez, Edmarie; Tranel, Daniel (2015) Does bilingualism contribute to cognitive reserve? Cognitive and neural perspectives. Neuropsychology 29:139-50
Derksen, B J; Duff, M C; Weldon, K et al. (2015) Older adults catch up to younger adults on a learning and memory task that involves collaborative social interaction. Memory 23:612-24
Kumaran, Dharshan; Warren, David E; Tranel, Daniel (2015) Damage to the Ventromedial Prefrontal Cortex Impairs Learning from Observed Outcomes. Cereb Cortex 25:4504-18
Ceschin, Rafael; Lee, Vince K; Schmithorst, Vince et al. (2015) Regional vulnerability of longitudinal cortical association connectivity: Associated with structural network topology alterations in preterm children with cerebral palsy. Neuroimage Clin 9:322-37
Hannula, Deborah E; Tranel, Daniel; Allen, John S et al. (2015) Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia. Neuropsychology 29:126-38

Showing the most recent 10 out of 353 publications