? This is a request for renewal of a Program on the neuroanatomical basis of cognition and behavior initiated in 1983, and renewed in 1986, 1991, 1996, and 2001. From the outset, the purposes of the Program have been: (1) to contribute to the understanding, diagnosis, and management of brain disease; (2) to elucidate, in hypothesis-driven research, the relation between large-scale human neural systems and functions such as emotion, decision-making, memory, and language; and (3) to maintain and expand a neurological Patient Registry, which constitutes a unique resource for cognitive neuroscience. The research relies on neurological lesions used as probes to test hypotheses regarding the role of cortical and subcortical systems involved in complex functions. The lesions are defined by in vivo neuroimaging techniques, and the functional impairments are characterized by neuropsychological and psychophysiological techniques. The approach is now strengthened by studies aimed at elucidating the pattern of interconnecting pathways in neural systems, and by the development of powerful new imaging and lesion analysis tools. The investigators have obtained results that have influenced cognitive neuroscience, and have provided a body of knowledge applicable to diagnostic procedures and valuable to inform the design of rehabilitation approaches. The renewal of this Program is likely to yield results of scientific merit and practical importance, potentially even stronger than in the past. The new proposal identifies exciting new questions to pursue, in lesion analysis, neuroeconomics, emotional and social development, social emotions, and memory and language disorders; it demonstrates the stability and cohesiveness of the senior research team, combined with the addition of a performance environment which will strengthen the intellectual and technical resources; and it maintains and expands the highly valuable resource of the Patient Registry. These factors join to provide ideal and compelling circumstances for continuation of the Program. ? ? Public health relevance: This research will provide information critical for the diagnosis and treatment of neurological patients who suffer stroke, head injury, brain tumors, seizure disorders, and other brain diseases. The information will help with the design of rehabilitation programs that can alleviate deficits in memory, language, and emotions, and help curb the suffering associated with brain disease. ?

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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Special Emphasis Panel (ZNS1-SRB-R (21))
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Babcock, Debra J
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University of Southern California
Schools of Arts and Sciences
Los Angeles
United States
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Mehta, Sonya; Inoue, Kayo; Rudrauf, David et al. (2016) Segregation of anterior temporal regions critical for retrieving names of unique and non-unique entities reflects underlying long-range connectivity. Cortex 75:1-19
Immordino-Yang, Mary Helen; Yang, Xiao-Fei; Damasio, Hanna (2016) Cultural modes of expressing emotions influence how emotions are experienced. Emotion 16:1033-9
Scherer, Aaron M; Taber-Thomas, Bradley C; Tranel, Daniel (2015) A neuropsychological investigation of decisional certainty. Neuropsychologia 70:206-13
Ceschin, Rafael; Wisnowski, Jessica L; Paquette, Lisa B et al. (2015) Developmental synergy between thalamic structure and interhemispheric connectivity in the visual system of preterm infants. Neuroimage Clin 8:462-72
Philippi, Carissa L; Tranel, Daniel; Duff, Melissa et al. (2015) Damage to the default mode network disrupts autobiographical memory retrieval. Soc Cogn Affect Neurosci 10:318-26
Guzmán-Vélez, Edmarie; Tranel, Daniel (2015) Does bilingualism contribute to cognitive reserve? Cognitive and neural perspectives. Neuropsychology 29:139-50
Derksen, B J; Duff, M C; Weldon, K et al. (2015) Older adults catch up to younger adults on a learning and memory task that involves collaborative social interaction. Memory 23:612-24
Kumaran, Dharshan; Warren, David E; Tranel, Daniel (2015) Damage to the Ventromedial Prefrontal Cortex Impairs Learning from Observed Outcomes. Cereb Cortex 25:4504-18
Ceschin, Rafael; Lee, Vince K; Schmithorst, Vince et al. (2015) Regional vulnerability of longitudinal cortical association connectivity: Associated with structural network topology alterations in preterm children with cerebral palsy. Neuroimage Clin 9:322-37
Hannula, Deborah E; Tranel, Daniel; Allen, John S et al. (2015) Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia. Neuropsychology 29:126-38

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