Abstract

Chemosensory dysfunction continues to affect 2 million adult Americans. In an attempt to deal with this problem, the previous grant developed safe biopsy techniques for human olfactory and gustatory epithelum, defined normal ultrastructure for both, and confirmed the hypothesis that ultrastructural changes occurred in dysfunctional patients. During the proposed renewal, we will focus on several specific dysfunctional states: Alzheimer's disease, post-viral anosmia, post-traumatic anosmia, post-laryngectomy """"""""anosmia"""""""", and ideopathic dysgeusia. We intend to study the ultrastructural changes in humans in conjunction with animal studies carried out by other members of the program project (e.g. studies with OMP-- Project #1, Na/K ATPase--Project #3, neuropeptide studies-- Project #5, and 3-dimensional computer reconstructions--Project #6). All of this should aid us in further understanding the dynamic changes in chemosensory receptors in humans. Thus, this project will have major clinical as well as basic science components.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS020486-04
Application #
3923240
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Moran, D T; Rowley 3rd, J C; Aiken, G R et al. (1992) Ultrastructural neurobiology of the olfactory mucosa of the brown trout, Salmo trutta. Microsc Res Tech 23:28-48
Bigiani, A R; Roper, S D (1991) Mediation of responses to calcium in taste cells by modulation of a potassium conductance. Science 252:126-8
Moran, D T; Jafek, B W; Rowley 3rd, J C (1991) The vomeronasal (Jacobson's) organ in man: ultrastructure and frequency of occurrence. J Steroid Biochem Mol Biol 39:545-52
Finger, T E; Womble, M; Kinnamon, J C et al. (1990) Synapsin I-like immunoreactivity in nerve fibers associated with lingual taste buds of the rat. J Comp Neurol 292:283-90
Rowley 3rd, J C; Moran, D T; Jafek, B W (1989) Peroxidase backfills suggest the mammalian olfactory epithelium contains a second morphologically distinct class of bipolar sensory neuron: the microvillar cell. Brain Res 502:387-400
Roper, S D; McBride Jr, D W (1989) Distribution of ion channels on taste cells and its relationship to chemosensory transduction. J Membr Biol 109:29-39
Roper, S D (1989) The cell biology of vertebrate taste receptors. Annu Rev Neurosci 12:329-53
Delay, R J; Roper, S D (1988) Ultrastructure of taste cells and synapses in the mudpuppy Necturus maculosus. J Comp Neurol 277:268-80
Kinnamon, S C (1988) Taste transduction: a diversity of mechanisms. Trends Neurosci 11:491-6
Kinnamon, S C; Roper, S D (1988) Membrane properties of isolated mudpuppy taste cells. J Gen Physiol 91:351-71

Showing the most recent 10 out of 16 publications