Abstract

The Scientific Core is a modest unit set up to facilitate the scientific projects within the program. The services and reagents provided by the Scientific Core are purified prions, bioassays, antibodies, synthetic peptides, and neuropathologic evaluations. The bioassay part of the Scientific Core obviously overlaps with the Animal Core. Most of the projects require purified prions, bioassays, antibodies to PrP peptides, and neuropathologic evaluations at least of selected animals. Two of the projects also use synthetic peptides. To provide these services and reagents, Dr. Stephen Dearmond, a skilled neuropathologist, and Dr. Dan Serban, a talented immunologist, are needed. In addition, the skills of Ms. Hana Serban and Ms. Darlene Groth are crucial to the smooth operation of the Scientific Core and the provision of purified prions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS022786-12
Application #
5215203
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Safar, Jiri G; Lessard, Pierre; Tamguney, Gultekin et al. (2008) Transmission and detection of prions in feces. J Infect Dis 198:81-9
Safar, Jiri G; Scott, Michael; Monaghan, Jeff et al. (2002) Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice. Nat Biotechnol 20:1147-50
Wilson, S M; Householder, D B; Coppola, V et al. (2001) Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice. Genomics 74:228-33
Safar, J; Cohen, F E; Prusiner, S B (2000) Quantitative traits of prion strains are enciphered in the conformation of the prion protein. Arch Virol Suppl :227-35
Stephenson, D A; Chiotti, K; Ebeling, C et al. (2000) Quantitative trait loci affecting prion incubation time in mice. Genomics 69:47-53
Williamson, R A; Peretz, D; Pinilla, C et al. (1998) Mapping the prion protein using recombinant antibodies. J Virol 72:9413-8
Safar, J; Wille, H; Itri, V et al. (1998) Eight prion strains have PrP(Sc) molecules with different conformations. Nat Med 4:1157-65
Carlson, G A; Banks, S; Lund, D et al. (1997) Failure to transmit disease from gray tremor mutant mice. J Virol 71:2342-5
Peretz, D; Williamson, R A; Matsunaga, Y et al. (1997) A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. J Mol Biol 273:614-22
Telling, G C; Haga, T; Torchia, M et al. (1996) Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev 10:1736-50

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