Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
3P01NS024304-04S1
Application #
3100128
Study Section
Neurological Disorders Program Project Review B Committee (NSPB)
Project Start
1987-01-01
Project End
1991-12-31
Budget Start
1990-02-01
Budget End
1990-12-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Fairclough, R H; Twaddle, G M; Gudipati, E et al. (1998) Mapping the mAb 383C epitope to alpha 2(187-199) of the Torpedo acetylcholine receptor on the three-dimensional model. J Mol Biol 282:301-15
Fairclough, R H; Twaddle, G M; Gudipati, E et al. (1998) Differential surface accessibility of alpha(187-199) in the Torpedo acetylcholine receptor alpha subunits. J Mol Biol 282:317-30
Richman, D P; Agius, M A; Kirvan, C A et al. (1998) Antibody effector mechanisms in myasthenia gravis. The complement hypothesis. Ann N Y Acad Sci 841:450-65
Fairclough, R H; Gudipati, E; Lin, M Y et al. (1998) A role for alpha(187-199) in the conversion of agonist binding energy to the opening of the acetylcholine receptor ion channel. Ann N Y Acad Sci 841:87-92
Richman, D P; Agius, M A (1994) Acquired myasthenia gravis. Immunopathology. Neurol Clin 12:273-84
Richman, D P; Agius, M A (1994) Myasthenia gravis: pathogenesis and treatment. Semin Neurol 14:106-10
Fairclough, R H; Josephs, R; Richman, D P (1993) Imaging ligand binding sites on the Torpedo acetylcholine receptor. Ann N Y Acad Sci 681:113-25
Xu, Q; Agius, M; Gudipati, E et al. (1993) An immunogenic self-peptide for T cells in mice with experimental myasthenia. Ann N Y Acad Sci 681:1-4
Xu, Q; Twaddle, G M; Richman, D P et al. (1993) Characterization of the epitope of an antiacetylcholine receptor antibody that inhibits fifty percent of alpha-bungarotoxin binding. Ann N Y Acad Sci 681:175-8
Xu, Q; Fairclough, R H; Richman, D P (1993) Interaction of antiacetylcholine receptor monoclonal antibodies with the acetylcholine receptor. Ann N Y Acad Sci 681:172-4

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