Abstract

The specific aims of the Vector Core for his PPG proposal are to I) prepare working stocks of previously generated recombinant viruses for investigators to perform gene transfer experiments, ii) test all viruses for helper virus and pfu/particle ratio, iii) assist in the evaluation of initial gene transfer studies by helping set up molecular and/or enzymatic assays. By providing these services, the Vector Core substantially reduces the overall cost and time of setting up routine vector production in each investigators laboratory.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS024621-13
Application #
6112281
Study Section
Project Start
1999-03-01
Project End
2000-02-29
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
13
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Ketsawatsomkron, Pimonrat; Keen, Henry L; Davis, Deborah R et al. (2016) Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-? Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension 67:214-22
Dayal, Sanjana; Gu, Sean X; Hutchins, Ryan D et al. (2015) Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis. Arterioscler Thromb Vasc Biol 35:1798-804
Rodionov, Roman N; Jarzebska, Natalia; Weiss, Norbert et al. (2014) AGXT2: a promiscuous aminotransferase. Trends Pharmacol Sci 35:575-82
De Silva, T Michael; Modrick, Mary L; Ketsawatsomkron, Pimonrat et al. (2014) Role of peroxisome proliferator-activated receptor-? in vascular muscle in the cerebral circulation. Hypertension 64:1088-93
Chrissobolis, Sophocles; Drummond, Grant R; Faraci, Frank M et al. (2014) Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. J Hypertens 32:1815-21
Khoo, Nicholas K H; Hebbar, Sachin; Zhao, Weiling et al. (2013) Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy. Redox Biol 1:70-9
Weiss, Robert M; Lund, Donald D; Chu, Yi et al. (2013) Osteoprotegerin inhibits aortic valve calcification and preserves valve function in hypercholesterolemic mice. PLoS One 8:e65201
Johnson, Andrew W; Kinzenbaw, Dale A; Modrick, Mary L et al. (2013) Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension. Hypertension 61:437-42
Chu, Yi; Lund, Donald D; Weiss, Robert M et al. (2013) Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. Arterioscler Thromb Vasc Biol 33:523-32
Klykov, Corinne M; Lentz, Steven R (2013) Trends in clinical laboratory homocysteine testing from 1997 to 2010: the impact of evidence on clinical practice at a single institution. Clin Chem Lab Med 51:671-5

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