Overall Objective:The purpose of this core is to provide centralized care, breeding, genotyping and quality control oftransgenic and knockout animals for use by investigators in the program project. The core willmaintain and distribute novel models for interrogating the importance of PPARy in the cerebralvasculature. The core will also provide a mechanism for the distribution of new experimentaltransgenic and knockout models to the Jackson Laboratory Induced Mutant Resource, and toprogram and non-program project investigators both at the University of Iowa and outside theinstitution. The core will implement the required 'NIH Sharing Plan' for novel animal models.The main responsibilities of the Core will be:Provision of novel PPAR knockin and transgenic miceMaintenance of genetic stocks of other gene targeted and transgenic miceGenotyping transgenic and knockout animalsProvision of experimental and control mice to investigatorsQuality Control
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