Abstract

The Administrative Core of this Program will provide centralized support functions for all Projects contained within the Cerebral Vascular Biology PPG, as well as for the Transgenic and Knockout Animal Core (Core B). All responsibilities of this Core will be carried out under the supervision of the Program Director, Dr. Faraci. If Dr. Faraci is temporarily unable to carry out the management of this Core, the Program Co-Director (Dr. Heistad) will assume this responsibility. This Core is essential for the coordination of research carried out under each Project, as well as to ensure that integrative studies and techniques relative to this Program are acted upon. The overall conduct of this Program is the ultimate responsibility of the Director. However, each Principle Investigator assumes individual responsibility for studies that are performed as part of their projects. Additional details regarding the organization and execution of this Core and included in the Program Introduction (Directors Summary).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS024621-24
Application #
8247098
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
24
Fiscal Year
2011
Total Cost
$113,424
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Ketsawatsomkron, Pimonrat; Keen, Henry L; Davis, Deborah R et al. (2016) Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-? Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension 67:214-22
Dayal, Sanjana; Gu, Sean X; Hutchins, Ryan D et al. (2015) Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis. Arterioscler Thromb Vasc Biol 35:1798-804
Rodionov, Roman N; Jarzebska, Natalia; Weiss, Norbert et al. (2014) AGXT2: a promiscuous aminotransferase. Trends Pharmacol Sci 35:575-82
De Silva, T Michael; Modrick, Mary L; Ketsawatsomkron, Pimonrat et al. (2014) Role of peroxisome proliferator-activated receptor-? in vascular muscle in the cerebral circulation. Hypertension 64:1088-93
Chrissobolis, Sophocles; Drummond, Grant R; Faraci, Frank M et al. (2014) Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. J Hypertens 32:1815-21
Khoo, Nicholas K H; Hebbar, Sachin; Zhao, Weiling et al. (2013) Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy. Redox Biol 1:70-9
Weiss, Robert M; Lund, Donald D; Chu, Yi et al. (2013) Osteoprotegerin inhibits aortic valve calcification and preserves valve function in hypercholesterolemic mice. PLoS One 8:e65201
Johnson, Andrew W; Kinzenbaw, Dale A; Modrick, Mary L et al. (2013) Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension. Hypertension 61:437-42
Chu, Yi; Lund, Donald D; Weiss, Robert M et al. (2013) Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. Arterioscler Thromb Vasc Biol 33:523-32
Klykov, Corinne M; Lentz, Steven R (2013) Trends in clinical laboratory homocysteine testing from 1997 to 2010: the impact of evidence on clinical practice at a single institution. Clin Chem Lab Med 51:671-5

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