Abstract

The Cores will serve several functions, including 1) centralized neurological and neuropsychological instrument assessment and development directed at improving the methods for evaluating the AIDS dementia complex for both clinical and epidemiological studies; 2) a virology core facility for HIV isolation from CSF and blood specimens obtained in the various clinical studies, 3) an immunological studies core to assess immune cell profiles and immune function in the various clinical studies, and 4) a data acquisition and analysis core to organize and maintain a centralized database system and for centralized biostatistical analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS025701-01
Application #
3923475
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Memorial Hospital for Cancer & Allied Di
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10021

  Publications

Price, R W; Yiannoutsos, C T; Clifford, D B et al. (1999) Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS Clinical Trial Group and Neurological AIDS Research Consortium study team. AIDS 13:1677-85
Rehm, K; Lakshminaryan, K; Frutiger, S et al. (1998) A symbolic environment for visualizing activated foci in functional neuroimaging datasets. Med Image Anal 2:215-26
Liow, J S; Strother, S C; Rehm, K et al. (1997) Improved resolution for PET volume imaging through three-dimensional iterative reconstruction. J Nucl Med 38:1623-31
Sidtis, J J; Dafni, U; Slasor, P et al. (1997) Stable neurological function in subjects treated with 2'3'-dideoxyinosine. J Neurovirol 3:233-40
Price, R W (1996) AIDS dementia complex: a complex, slow virus ""model"" of acquired genetic neurodegenerative disease. Cold Spring Harb Symp Quant Biol 61:759-70
Rottenberg, D A; Sidtis, J J; Strother, S C et al. (1996) Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia. J Nucl Med 37:1133-41
Wang, G J; Thayer, S A (1996) Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons. J Neurophysiol 76:1611-21
Price, R W (1996) The cellular basis of central nervous system HIV-1 infection and the AIDS dementia complex: introduction. J NeuroAIDS 1:1-29
Price, R W (1996) Neurological complications of HIV infection. Lancet 348:445-52
Price, R W (1995) Management of AIDS dementia complex and HIV-1 infection of the nervous system. AIDS 9 Suppl A:S221-36

Showing the most recent 10 out of 45 publications