The Core will support several basic functions of this program, including: (1) maintenance of a well-characterized group of HIV-1 seropositive subjects; (2) maintenance of a data acquisition, management, and analysis unit to manage a centralized database system and provide support for statistical analysis; (3) maintenance of a repository for clinical cerebrospinal fluid (CSF) and blood specimens characterized by """"""""routine"""""""" virological and immunological assessments; and (4) maintenance of a pathological specimen processing unit and library, including characterization of tissue by """"""""routine"""""""" pathological and immunohistochemical methods.

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Rottenberg, D A; Sidtis, J J; Strother, S C et al. (1996) Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia. J Nucl Med 37:1133-41
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Price, R W (1995) Management of AIDS dementia complex and HIV-1 infection of the nervous system. AIDS 9 Suppl A:S221-36

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