Abstract

The Core will support several basic functions of this program, including: (1) maintenance of a well-characterized group of HIV-1 seropositive subjects; (2) maintenance of a data acquisition, management, and analysis unit to manage a centralized database system and provide support for statistical analysis; (3) maintenance of a repository for clinical cerebrospinal fluid (CSF) and blood specimens characterized by """"""""routine"""""""" virological and immunological assessments; and (4) maintenance of a pathological specimen processing unit and library, including characterization of tissue by """"""""routine"""""""" pathological and immunohistochemical methods.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS025701-10
Application #
5215271
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Price, R W; Yiannoutsos, C T; Clifford, D B et al. (1999) Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS Clinical Trial Group and Neurological AIDS Research Consortium study team. AIDS 13:1677-85
Rehm, K; Lakshminaryan, K; Frutiger, S et al. (1998) A symbolic environment for visualizing activated foci in functional neuroimaging datasets. Med Image Anal 2:215-26
Liow, J S; Strother, S C; Rehm, K et al. (1997) Improved resolution for PET volume imaging through three-dimensional iterative reconstruction. J Nucl Med 38:1623-31
Sidtis, J J; Dafni, U; Slasor, P et al. (1997) Stable neurological function in subjects treated with 2'3'-dideoxyinosine. J Neurovirol 3:233-40
Price, R W (1996) AIDS dementia complex: a complex, slow virus ""model"" of acquired genetic neurodegenerative disease. Cold Spring Harb Symp Quant Biol 61:759-70
Rottenberg, D A; Sidtis, J J; Strother, S C et al. (1996) Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia. J Nucl Med 37:1133-41
Wang, G J; Thayer, S A (1996) Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons. J Neurophysiol 76:1611-21
Price, R W (1996) The cellular basis of central nervous system HIV-1 infection and the AIDS dementia complex: introduction. J NeuroAIDS 1:1-29
Price, R W (1996) Neurological complications of HIV infection. Lancet 348:445-52
Price, R W (1995) Management of AIDS dementia complex and HIV-1 infection of the nervous system. AIDS 9 Suppl A:S221-36

Showing the most recent 10 out of 45 publications