Abstract

COMPREHENSIVE PERINATAL AIDS RESEARCH CENTER This application requests support for studies of perinatal infections produced by human immunodeficiency virus (HIV) with special emphasis on three general areas: 1) humoral and cellular components of maternal immune responses to HIV and their influence on virus-transmission to the newborn 2) risk factors and mechanisms underlying neurologic complications of pediatric HIV infections, and 3) immunologic approaches to the prevention or attenuation of these infections. Collectively, the proposed studies represent an integrated effort by both clinical and laboratory-based researchers to target diverse investigative skills on a population that is especially prone to HIV-induced CNS dysfunction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS026665-03
Application #
3100256
Study Section
Special Emphasis Panel (SRC (07))
Project Start
1988-07-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Farley, J J; King Jr, J C; Nair, P et al. (1994) Invasive pneumococcal disease among infected and uninfected children of mothers with human immunodeficiency virus infection. J Pediatr 124:853-8
Farley, J J; Bauer, G; Johnson, J P et al. (1994) Phytohemagglutinin-inducible p24 in peripheral blood mononuclear cells as a predictor of human immunodeficiency virus type 1 vertical transmission and infant clinical status. Pediatr Infect Dis J 13:1079-82
Archibald, D W; Farley Jr, J J; Hebert, C A et al. (1993) Practical applications for saliva in perinatal HIV diagnosis. Ann N Y Acad Sci 694:195-201
Archibald, D W; Hebert, C A (1991) Salivary detection of HIV-1 antibodies using recombinant HIV-1 peptides. Viral Immunol 4:17-22
Cole, G A; Bauer, G; Kirsten, E et al. (1991) Inhibition of HIV-1 IIIb replication in AA-2 and MT-2 cells in culture by two ligands of poly (ADP-ribose) polymerase: 6-amino-1,2-benzopyrone and 5-iodo-6-amino-1,2-benzopyrone. Biochem Biophys Res Commun 180:504-14
Archibald, D W; Hebert, C A; Sun, D et al. (1990) Salivary antibodies to human immunodeficiency virus type 1 in a phase I AIDS vaccine trial. J Acquir Immune Defic Syndr 3:954-8
Archibald, D W; Cole, G A (1990) In vitro inhibition of HIV-1 infectivity by human salivas. AIDS Res Hum Retroviruses 6:1425-32
Archibald, D W; Johnson, J P; Nair, P et al. (1990) Detection of salivary immunoglobulin A antibodies to HIV-1 in infants and children. AIDS 4:417-20