Abstract

The animal surgery core will provide the rabbit spinal cord ischemia model (RSCIM), rat fimbria-fornix (FF) and rat perforant path (PP) transection models for all the investigators involved in this program. These models permit in vivo pharmacological studies of the neurotrophic factors and related molecules that will be tested for efficacy in developing new treatments for stroke and central nervous system trauma. These models can also be used to supply tissues for biochemical studies of the effects of acute damage on the central nervous system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS028121-08
Application #
6112345
Study Section
Project Start
1998-06-01
Project End
2000-05-31
Budget Start
Budget End
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Maher, Pamela (2014) Proteasome Assay in Cell Lysates. Bio Protoc 4:
Brennand, K J; Simone, A; Tran, N et al. (2012) Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry 17:1239-53
Brennand, Kristen J; Simone, Anthony; Jou, Jessica et al. (2011) Modelling schizophrenia using human induced pluripotent stem cells. Nature 473:221-5
Brennand, Kristen J; Gage, Fred H (2011) Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia. Stem Cells 29:1915-22
Maher, Pamela (2008) Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism. Biochem Pharmacol 75:1994-2006
Maher, Pamela (2008) The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity. Arch Biochem Biophys 476:139-44
Maher, Pamela; Salgado, Karmen F; Zivin, Justin A et al. (2007) A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res 1173:117-25
Lapchak, Paul A (2006) 3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator. Exp Neurol 197:531-7
Maher, Pamela; Akaishi, Tatsuhiro; Abe, Kazuho (2006) Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A 103:16568-73
Hanneken, Anne; Lin, Fen-Fen; Johnson, Jennifer et al. (2006) Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. Invest Ophthalmol Vis Sci 47:3164-77

Showing the most recent 10 out of 142 publications