The Core houses a repository of brain specimens from patients who died with HIV-1 infection and AIDS. This consists largely of pediatric cases, with a small number of adult cases aswell. There is currently paraffin-embedded tissue from 79 cases, with specimens snap frozen in isopentane cooled with liquid nitrogen and stored at -80 degrees C from 24 of these cases, with many collected within 12 hours of death. Because of the success of treatment of pediatric AIDS with highly active antiretroviral therapy (HAART), the number of deaths due to HIV-1 has fallen, with a consequent diminution in the number of cases added to the Brain Bank over the last few years. Any cases that do come to post mortem examination, with proper consent for autopsy, will be added to the Brain Bank, with an expected maximum of three cases per year (see letter from consultant, Dr. George McSherry, of the Division of Pediatric Allergy, Immunology and Infectious Diseases, and of the pediatric AIDS center at University Hospital, Newark). Inthe autopsy protocol, the brain is divided in half, with samples taken from over 20 regions for snap freezing from one half, while over 50 regions are sampled for paraffin embedding from the other half.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS031492-11
Application #
6703171
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2003-09-01
Project End
2008-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
11
Fiscal Year
2003
Total Cost
$214,874
Indirect Cost
Name
St. Luke's-Roosevelt Institute for Health Sciences
Department
Type
DUNS #
623216371
City
New York
State
NY
Country
United States
Zip Code
10019
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