This Project will evaluate the effectiveness of cytosine arabinoside for treatment of biopsy proven progressive multifocal leukoencephalopathy in subjects with human immunodeficiency virus infection. A three arm study comparing best possible anti-retroviral therapy with either intravenous ARA-C therapy administered through an Ommaya reservoir. Twenty patients will be randomized to each arm of the study. The primary endpoint is death within 24 weeks. Secondary end points will be neurologic deterioration as indicated by neurologic examination and deterioration in Karnofsky Performance Scores.
| Schifitto, G; Sacktor, N; Marder, K et al. (1999) Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium. Neurology 53:391-6 |
| Singer, E J; Kim, J; Fahy-Chandon, B et al. (1996) Headache in ambulatory HIV-1-infected men enrolled in a longitudinal study. Neurology 47:487-94 |
| Paskavitz, J F; Anderson, C A; Filley, C M et al. (1995) Acute arcuate fiber demyelinating encephalopathy following Epstein-Barr virus infection. Ann Neurol 38:127-31 |
| Clifford, D B (1995) Neurologic opportunistic infections. Curr Opin Neurol 8:175-8 |
| Tyler, K L; Sandberg, E; Baum, K F (1994) Medical medullary syndrome and meningovascular syphilis: a case report in an HIV-infected man and a review of the literature. Neurology 44:2231-5 |
