Abstract

The Scientific Core provides an organizational structure for scientific efforts common to all projects within the program. This Core provides 5% support for the Program Director. The Program Director meets with the Clinical Coordinator daily to prioritize scientific efforts on all human and monkey specimens received, and meets with the DNA data analyzer at least twice weekly to coordinate sequencing priorities, plan strategies and evaluate data. The Scientific Core provides 100% support for the Clinical Coordinator whose efforts are devoted to acquiring, banking, processing and computerizing all tissue from humans in Projects 1 and 3 and from monkeys in Project 2. The Scientific Core also provides 100% support for the DNA data analyst whose expertise in storage and analysis of DNA sequences is required for all three projects. In addition, the Scientific Core provides support for external consultants necessary for annual scientific evaluation of the Program Project. Finally, the Scientific Core provides support forcommon-use equipment, service contracts and all editorial review and publication expenses apportioned to the Program Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS032623-16A1
Application #
6746069
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2003-12-01
Project End
2008-11-30
Budget Start
2003-12-01
Budget End
2005-01-31
Support Year
16
Fiscal Year
2004
Total Cost
$178,618
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Cohrs, Randall J; Lee, Katherine S; Beach, Addilynn et al. (2017) Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion. J Virol 91:
Ouwendijk, Werner J D; van Veen, Suzanne; Mahalingam, Ravi et al. (2017) Simian varicella virus inhibits the interferon gamma signalling pathway. J Gen Virol :
Ouwendijk, Werner J D; Getu, Sarah; Mahalingam, Ravi et al. (2016) Characterization of the immune response in ganglia after primary simian varicella virus infection. J Neurovirol 22:376-88
Birlea, Marius; Owens, Gregory P; Eshleman, Emily M et al. (2013) Human anti-varicella-zoster virus (VZV) recombinant monoclonal antibody produced after Zostavax immunization recognizes the gH/gL complex and neutralizes VZV infection. J Virol 87:415-21
Mueller, Niklaus H; Bos, Nathan L; Seitz, Scott et al. (2012) Recombinant monoclonal antibody recognizes a unique epitope on varicella-zoster virus immediate-early 63 protein. J Virol 86:6345-9
Nagel, Maria A; Bert, Robert J; Gilden, Don (2012) Raeder syndrome produced by extension of chronic inflammation to the internal carotid artery. Neurology 79:1296-7
Wolf, James; Nagel, Maria A; Mahalingam, Ravi et al. (2012) Chronic active varicella zoster virus infection. Neurology 79:828-9
Brennan, Kathryn M; Galban-Horcajo, Francesc; Rinaldi, Simon et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. J Neuroimmunol 238:87-95
Haug, Aaron; Mahalingam, Ravi; Cohrs, Randall J et al. (2010) Recurrent polymorphonuclear pleocytosis with increased red blood cells caused by varicella zoster virus infection of the central nervous system: Case report and review of the literature. J Neurol Sci 292:85-8
Mahalingam, Ravi; Traina-Dorge, Vicki; Wellish, Mary et al. (2010) Latent simian varicella virus reactivates in monkeys treated with tacrolimus with or without exposure to irradiation. J Neurovirol 16:342-54

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