Project Start
2000-05-01
Project End
2002-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2000
Total Cost
$242,910
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Ho, Ruth; Eggert, Angelika; Hishiki, Tomoro et al. (2002) Resistance to chemotherapy mediated by TrkB in neuroblastomas. Cancer Res 62:6462-6
Eggert, A; Grotzer, M A; Zuzak, T J et al. (2002) Expression of Apo-3 and Apo-3L in primitive neuroectodermal tumours of the central and peripheral nervous system. Eur J Cancer 38:92-8
Tang, X X; Evans, A E; Zhao, H et al. (2001) Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas. Med Pediatr Oncol 36:80-2
Eggert, A; Grotzer, M A; Zuzak, T J et al. (2001) Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Cancer Res 61:1314-9
Grotzer, M A; Wiewrodt, R; Janss, A J et al. (2001) High microvessel density in primitive neuroectodermal brain tumors of childhood. Neuropediatrics 32:75-9
Grotzer, M A; Janss, A J; Fung, K M et al. (2001) Abundance of apoptotic neoplastic cells in diagnostic biopsy samples is not a prognostic factor in childhood primitive neuroectodermal tumors of the central nervous system. J Pediatr Hematol Oncol 23:25-9
Grotzer, M A; Geoerger, B; Janss, A J et al. (2001) Prognostic significance of Ki-67 (MIB-1) proliferation index in childhood primitive neuroectodermal tumors of the central nervous system. Med Pediatr Oncol 36:268-73
Geoerger, B; Kerr, K; Tang, C B et al. (2001) Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res 61:1527-32
Evans, A E; Kisselbach, K D; Liu, X et al. (2001) Effect of CEP-751 (KT-6587) on neuroblastoma xenografts expressing TrkB. Med Pediatr Oncol 36:181-4
Eggert, A; Grotzer, M A; Ikegaki, N et al. (2001) Expression of the neurotrophin receptor TrkB is associated with unfavorable outcome in Wilms' tumor. J Clin Oncol 19:689-96

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