Therapeutic Approaches to Experimental Dementias

Manuelidis, Laura

Abstract

We continue to evaluate in our animal models, selected drugs that may have therapeutic potential in CJD. Additionally, we will define by in vitro studies the molecular basis of CJD induced changes in membrane function (adenyl cyclase), and characterize the effects of pharmacologic agents which have the theoretical potential to reverse these effects.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Program Projects (P01)
• Project #: 5P01NS034569-12
• Application #: 5215543
• Support Year: 12
• Fiscal Year: 1996

Publications

Gomez-Varela, David; Berg, Darwin K (2013) Lateral mobility of presynaptic ?7-containing nicotinic receptors and its relevance for glutamate release. J Neurosci 33:17062-71

Wang, Xulong; Lippi, Giordano; Carlson, David M et al. (2013) Activation of ?7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. J Neurochem 127:632-43

Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Glutamatergic synapse formation is promoted by ?7-containing nicotinic acetylcholine receptors. J Neurosci 32:7651-61

Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Induction of dendritic spines by ?2-containing nicotinic receptors. J Neurosci 32:8391-400

Gómez-Varela, David; Schmidt, Manuela; Schoellerman, Jeff et al. (2012) PMCA2 via PSD-95 controls calcium signaling by ?7-containing nicotinic acetylcholine receptors on aspiny interneurons. J Neurosci 32:6894-905

Arjona, Alvaro; Simarro, Laura; Islinger, Florian et al. (2004) Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures. Proc Natl Acad Sci U S A 101:8768-73

Baker, Christopher A; Lu, Zhi Yun; Manuelidis, Laura (2004) Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. J Neurovirol 10:29-40

Baker, Christopher A; Manuelidis, Laura (2003) Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:675-9

Manuelidis, Laura; Lu, Zhi Yun (2003) Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:5360-5

Manuelidis, Laura (2003) Transmissible encephalopathies: speculations and realities. Viral Immunol 16:123-39