Abstract

Our purpose here is to further evaluate the influence of host genetics on CJD disease. Specifically, incubation time, pathological sequelae (morphological and biochemical) and host genetic markers will be evaluated. Two major models are proposed for these studies: 1) CJD in various inbred strains of hamsters and 2) mouse inbred strains that show destructive white matter lesions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
3P01NS034569-13
Application #
6243873
Study Section
Project Start
1997-03-01
Project End
1998-02-28
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
13
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Gomez-Varela, David; Berg, Darwin K (2013) Lateral mobility of presynaptic ?7-containing nicotinic receptors and its relevance for glutamate release. J Neurosci 33:17062-71
Wang, Xulong; Lippi, Giordano; Carlson, David M et al. (2013) Activation of ?7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. J Neurochem 127:632-43
Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Induction of dendritic spines by ?2-containing nicotinic receptors. J Neurosci 32:8391-400
Gómez-Varela, David; Schmidt, Manuela; Schoellerman, Jeff et al. (2012) PMCA2 via PSD-95 controls calcium signaling by ?7-containing nicotinic acetylcholine receptors on aspiny interneurons. J Neurosci 32:6894-905
Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Glutamatergic synapse formation is promoted by ?7-containing nicotinic acetylcholine receptors. J Neurosci 32:7651-61
Arjona, Alvaro; Simarro, Laura; Islinger, Florian et al. (2004) Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures. Proc Natl Acad Sci U S A 101:8768-73
Baker, Christopher A; Lu, Zhi Yun; Manuelidis, Laura (2004) Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. J Neurovirol 10:29-40
Baker, Christopher A; Manuelidis, Laura (2003) Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:675-9
Manuelidis, Laura; Lu, Zhi Yun (2003) Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:5360-5
Manuelidis, Laura (2003) Transmissible encephalopathies: speculations and realities. Viral Immunol 16:123-39

Showing the most recent 10 out of 25 publications