Abstract

We shall investigate in depth rodent models of CJD agent variants derived from human Gerstmann-Straussler-Scheinker cases and from progressive infantile encephalopathies (so called """"""""Alper's disease""""""""). We have already transmitted several of these cases in our laboratory to rodents. In the existing animal models of these diseases we will focus on incubation time, infectious titer and variations in pathological sequelae. As well, DNA and RNA from both human material (CJD, GSS and AD) and variant CJD isolates in rodents will be prepared for investigation of pertinent host genetic studies and for later use with selected cDNA probes (see Projects IVB, V, VI).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
3P01NS034569-14
Application #
6273893
Study Section
Project Start
1998-03-01
Project End
1999-02-28
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
14
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Gomez-Varela, David; Berg, Darwin K (2013) Lateral mobility of presynaptic ?7-containing nicotinic receptors and its relevance for glutamate release. J Neurosci 33:17062-71
Wang, Xulong; Lippi, Giordano; Carlson, David M et al. (2013) Activation of ?7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. J Neurochem 127:632-43
Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Glutamatergic synapse formation is promoted by ?7-containing nicotinic acetylcholine receptors. J Neurosci 32:7651-61
Lozada, Adrian F; Wang, Xulong; Gounko, Natalia V et al. (2012) Induction of dendritic spines by ?2-containing nicotinic receptors. J Neurosci 32:8391-400
Gómez-Varela, David; Schmidt, Manuela; Schoellerman, Jeff et al. (2012) PMCA2 via PSD-95 controls calcium signaling by ?7-containing nicotinic acetylcholine receptors on aspiny interneurons. J Neurosci 32:6894-905
Arjona, Alvaro; Simarro, Laura; Islinger, Florian et al. (2004) Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures. Proc Natl Acad Sci U S A 101:8768-73
Baker, Christopher A; Lu, Zhi Yun; Manuelidis, Laura (2004) Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. J Neurovirol 10:29-40
Baker, Christopher A; Manuelidis, Laura (2003) Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:675-9
Manuelidis, Laura; Lu, Zhi Yun (2003) Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 100:5360-5
Manuelidis, Laura (2003) Transmissible encephalopathies: speculations and realities. Viral Immunol 16:123-39

Showing the most recent 10 out of 25 publications