Abstract

The PET Image Analysis Core will provide a shared resource for implementation and standardization of image analysis software compatible with the Siemens ECAT EXACT HR scanner. The Image Analysis Core will test and implement software for alignment of images with subjects including within study and across study alignment of H2 15O,C15O and O15O images and registration of PET with CT images. A correction for partial volume effect from intracerebral hematomas and cerebrospinal fluid bases on the CT scan also will tested and implemented. The effect of different reconstruction filters and different region of interest sizes on regional physiological measurements will be investigated to determine the best combination to maximize both accuracy and spatial resolution. Software to permit analysis of within subject changes based on generation of histograms of defined ranges of values of physiological measurements will be tested and implemented. Standardized image processing will be applied to a control group of patients with carotid occlusion and normal Ct scans who were asymptomatic at the time of PET to provide data on minimum regional values rCBF and rCMRO2, OEF and CvO2 that are still compatible with brain function and viability.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS035966-04
Application #
6347671
Study Section
Project Start
2000-06-01
Project End
2001-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2000
Total Cost
$121,168
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Dhar, Rajat; Zazulia, Allyson R; Derdeyn, Colin P et al. (2017) RBC Transfusion Improves Cerebral Oxygen Delivery in Subarachnoid Hemorrhage. Crit Care Med 45:653-659
Lee, J J; Powers, W J; Faulkner, C B et al. (2013) The Kety-Schmidt technique for quantitative perfusion and oxygen metabolism measurements in the MR imaging environment. AJNR Am J Neuroradiol 34:E100-2
Scalfani, Michael T; Dhar, Rajat; Zazulia, Allyson R et al. (2012) Effect of osmotic agents on regional cerebral blood flow in traumatic brain injury. J Crit Care 27:526.e7-12
Diringer, Michael N; Scalfani, Michael T; Zazulia, Allyson R et al. (2012) Effect of mannitol on cerebral blood volume in patients with head injury. Neurosurgery 70:1215-8; discussion 1219
Powers, William J; Haas, Richard H; Le, Thuy et al. (2011) Platelet mitochondrial complex I and I+III activities do not correlate with cerebral mitochondrial oxidative metabolism. J Cereb Blood Flow Metab 31:e1-5
Powers, William J; Videen, Tom O; Markham, Joanne et al. (2011) Metabolic control of resting hemispheric cerebral blood flow is oxidative, not glycolytic. J Cereb Blood Flow Metab 31:1223-8
Zazulia, Allyson R; Videen, Tom O; Diringer, Michael N et al. (2011) Poor correlation between perihematomal MRI hyperintensity and brain swelling after intracerebral hemorrhage. Neurocrit Care 15:436-41
Powers, William J; Zazulia, Allyson R (2010) PET in Cerebrovascular Disease. PET Clin 5:83106
Powers, William J (2010) Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury. Stroke 41:S107-10
Sampson, Tomoko R; Dhar, Rajat; Diringer, Michael N (2010) Factors associated with the development of anemia after subarachnoid hemorrhage. Neurocrit Care 12:4-9

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